Balancing of Patients Treated by Vitamin K Antagonists (VKAS) in General Medicine

Despite the rise in prescriptions for direct oral anticoagulants, Vitamin K antagonists (VKA) remains the most prescribed treatment for treating and preventing long-term thromboembolic events. They remain the most important drugs of iatrogenic accidents despite the means deployed by the health authorities. The balance of the patients under VKA can be appreciated thanks to the time spent in the therapeutic zone or TTR which is correlated with the risk of occurrence of haemorrhagic or thrombotic events.

The management of VKA in France seems hardly comparable to that of the neighboring countries in front of:

• A TTR estimated at 60%.
• Majority management of anticoagulant treatments by general practitioners.
• The weak development of clinics anticoagulants.
• The takeoff of direct oral anticoagulant prescriptions.
• Preponderance of fluindione prescriptions among the various oral anticoagulants.

It therefore seems interesting to study a cohort of French patients under VKA. Through the calculation of the TTR, the investigators will be able to draw a picture of the balance of the anticoagulant treatment and try to identify factors that can influence it.

Inclusion criteria

• Patient treated with VKA.
• Realization of INR in one of the labs of the territory of LaboSud Oc biology between 1 September 2015 and 13 January 2016.

Exclusion criteria

• Less than 3 INR during the data collection period (TTR calculation not possible).
• Time greater than 56 days between two INRs (calculation of the invalid TTR).
• Interrupted treatment (calculation of invalid TTR).
• Lack of information about the patient