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OpenTrials
Completed

NCT Number: NCT03494894

Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia

Cytobacteriological examination of sputum and bacteriological sampling in the middle meatus.

Completed

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Key information

Conditions

Cystic Fibrosis Abnormalities, Multiple Ciliary Motility Disorders Ciliopathies Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Genetic Diseases, Inborn Infant, Newborn, Diseases Lung Diseases Otorhinolaryngologic Diseases Pancreatic Diseases Primary Ciliary Dyskinesia Respiratory Tract Diseases

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Intercommunal de Créteil

Créteil, 94000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 6 years old
  • Patients with cystic fibrosis or primary ciliary dyskinesia.
  • Patients capable of performing an expectorations
  • Patients having been informed of the research, having received the information note and not having opposed the research

Exclusion criteria

  • Refusal to participate in the study

Treatment and study plan

Middle meatus aspirations and sputum

Diagnostic Test

Bacterial genotype sequencing analysis will be performed in patients with bacteriological concordance between upper and lower airways.

Primary outcomes

  1. Presence of bacterial colonization of the upper and lower airway

    Time frame: 1 day

Secondary outcomes

  1. bacteriological concordance

    Time frame: 1 day

    bacteriological concordance of upper airways (VAS) and lower (VAI) between patients with cystic fibrosis and those with primary ciliary dyskinesia.

  2. bacteria genotype

    Time frame: 1 day

    Compare the genotype of bacteria present in both VAS and VAI.

  3. bacteriological concordance in children

    Time frame: 1 day

    Subgroup analysis (group <18 years old)

  4. bacteriological concordance in adult

    Time frame: 1 day

    Subgroup analysis (adult group)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Intercommunal Creteil

Other

Registry information

Acronym: BAVASI

Important dates

Study start
2017
Primary completion
2017
Study completion
2019
First posted
Apr 11, 2018
Registry last updated
Aug 4, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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