Azithromycin for Preventing Maternal and Neonatal Infections During Labor.

In this study, we want to see the role of the antibiotic, azithromycin, in preventing maternal and neonatal infections, if the drug is given intrapartum to the mother

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Key information

Conditions

Maternal and Neonatal Sepsis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Infant, Newborn, Diseases Infections Inflammation Intrapartum Antibiotics Neonatal Sepsis Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

pregnant ladies with no risk factors for sepsis who go into spontaneous labor or induced labor

Exclusion criteria

pregnant with risk factors for sepsis like maternal fever , raised WBC count, chorioamnionitis, or having. history of any adverse even with macrolides

Treatment and study plan

oral azithromycin

Drug

we will be administering single-dose oral azithromycin to ladies who go into labor and have no risk factors for sepsis, as there is increased risk of postpartum sepsis in both mother and neonate after normal vaginal delivery in low-income and middle-income countries

no azithromycin

Other

participants in this arm will be given only standard labor care and no oral azithromycin

Primary outcomes

maternal infections

Time frame: birth to 6 weeks post partum

Secondary outcomes

neonatal infections

Time frame: birth to 6 weeks post partum

Sponsors and collaborators

Lead sponsor

Armed Forces Hospital, Pakistan

Other

Registry information

Official study title

Impact of Single Dose Azithromycin During Labor on Maternal and Neonatal Infections

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: May 6, 2025
Registry last updated: May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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