Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease

Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.

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Key information

Conditions

Diabetes Mellitus Cardiovascular Diseases Chronic Nephropathy Endocrine System Diseases Essential Hypertension Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Hypertension Kidney Diseases Male Urogenital Diseases Metabolic Diseases Nutritional and Metabolic Diseases Renal Failure Renal Insufficiency Urogenital Diseases Urologic Diseases Vascular Diseases

Age range

20 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Yokohama City University Center Hospital

Yokohama, 232-0024, Japan

About this study

The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance. Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Hypertensive patients with diabetes mellitus
Hypertensive patients
Hypertensive patients with renal disease
Patients with chronic renal disease

Exclusion criteria

Cardiac, hematologic or hepatic disease
Cerebral infarction or hemorrhage
Other major diseases.

Treatment and study plan

Ambulatory blood pressure monitoring

Device

Sponsors and collaborators

Lead sponsor

Yokohama City University Medical Center

Other

Registry information

Important dates

Study start: 2004
Study completion: 2006
First posted: Mar 1, 2006
Registry last updated: May 9, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed