Autologous Blood Products in Ridge Preservation

This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction.

After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes.

In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period.

Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care.

The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Ridge Preservation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Çanakkale Onsekiz Mart University

Çanakkale, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
No history of blood-borne infectious diseases
Non-smokers
Age ≥18 years
Patients requiring extraction of a single-rooted tooth in the maxilla or mandible
Availability of a pre-existing CBCT scan of the planned extraction site
Extraction site suitable for implant placement

Exclusion criteria

Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
Presence of blood-borne infectious diseases
Smoking habit
Age <18 years
Psychological or mental conditions that may affect compliance with treatment or study participation
Extraction sites not suitable for implant placement
History of previous surgical intervention or compromised healing in the extraction site
Pregnancy

Treatment and study plan

Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application

Procedure

Following atraumatic tooth extraction under local anesthesia, autologous blood will be collected from the patient. Titanium platelet-rich fibrin (T-PRF) will be prepared by centrifugation of blood in titanium tubes, and injectable platelet-rich fibrin (i-PRF) will be obtained using a low-speed centrifugation protocol.

The prepared i-PRF will be injected into the T-PRF membrane to create a combined autologous fibrin construct. This material will then be placed into the extraction socket to support clot stability and tissue regeneration, and the site will be sutured for stabilization.

This approach combines the dense fibrin structure of T-PRF with the biological activity of i-PRF, aiming to enhance angiogenesis, soft and hard tissue healing, and preservation of alveolar ridge dimensions.

Primary outcomes

Horizontal Bone Width Change (CBCT Analysis)

Time frame: 6 month

Evaluation of horizontal bone width in millimeters at standardized levels (1 mm, 3 mm, and 5 mm from the alveolar crest) using CBCT at baseline (immediately after extraction) and 6 months

Sponsors and collaborators

Lead sponsor

Çanakkale Onsekiz Mart University

Other

Registry information

Official study title

Clinical, Radiological, and Ultrasonographic Evaluation of Autologous Blood Products in Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Apr 15, 2026
Registry last updated: Apr 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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