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OpenTrials
Completed

NCT Number: NCT02805231

Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

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Key information

Conditions

Primary Open- Angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

55 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion criteria

  • the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Treatment and study plan

Vitamin D receptor polymorphic analysis

Other

Primary outcomes

  1. gene polymorphisms of vitamin D receptor

    Time frame: 1 day visit

Sponsors and collaborators

Lead sponsor

Lv Yingjuan

Other

Collaborators

  • Tianjin Medical University Eye Hospital

Registry information

Official study title

Associations of Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Jun 17, 2016
Registry last updated
Jan 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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