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Completed

NCT Number: NCT02539745

Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

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Key information

Conditions

Vitamin D Deficiency Avitaminosis Deficiency Diseases Eye Diseases Glaucoma Glaucoma, Open-Angle Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Ocular Hypertension Primary Open- Angle Glaucoma

Age range

55 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tianjin Medical University Eye Hospital

Tianjin, Tianjin Municipality, 300384, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • intraocular pressure greater than 22 mmHg with two or more medications
  • wide anterior chamber angle
  • glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect)
  • visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion criteria

  • the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma
  • high myopia
  • macular degeneration
  • other ocular diseases
  • a known history of systemic diseases and administration of vitamin D3 or other analog

Treatment and study plan

Vitamin D receptor polymorphic analysis

Other

Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

Serum levels of 1a, 25-Dihydroxyvitamin D3

Other

Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay.

Primary outcomes

  1. Serum levels of 1a, 25-Dihydroxyvitamin D3

    Time frame: 1 day visit

Secondary outcomes

  1. gene polymorphisms of vitamin D receptor

    Time frame: 1 day visit

Sponsors and collaborators

Lead sponsor

Lv Yingjuan

Other

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Sep 3, 2015
Registry last updated
Apr 22, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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