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Completed

NCT Number: NCT07454876

Association of TLR7 Gene rs3853839 Polymorphism With Disease Severity in Alopecia Areata: A Case-Control Study

Alopecia areata is an autoimmune, non-scarring hair loss disorder characterized by variable clinical severity. Toll-like receptor 7 (TLR7) plays a key role in innate immune activation and autoimmune responses. The rs3853839 polymorphism of the TLR7 gene has been implicated in immune-mediated diseases. This study aims to evaluate the association between TLR7 rs3853839 polymorphism and susceptibility to alopecia areata, and to assess its correlation with disease severity measured by the Severity of Alopecia Tool (SALT) score.

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Key information

Conditions

Alopecia Areata Alopecia Hair Diseases Hypotrichosis Skin Diseases Skin and Connective Tissue Diseases TLRs

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Principal Investigator

Banhā, Qalyubia Governorate, 13511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Cases):

  • Clinical diagnosis of alopecia areata
  • Age ≥ 18 years
  • Both genders
  • Provision of written informed consent

Inclusion criteria

(Controls):

  • Apparently healthy individuals
  • No personal or family history of autoimmune disease
  • Age- and sex-matched to patient group
  • Provision of written informed consent

Exclusion criteria

  • Presence of other autoimmune or inflammatory disorders
  • Current systemic immunosuppressive therapy
  • Pregnancy or lactation
  • Refusal to participate

Exclusion criteria

-

Treatment and study plan

Primary outcomes

  1. Genotype and Allele Frequency Distribution of TLR7 rs3853839

    Time frame: Baseline

    Comparison of genotype and allele frequencies of TLR7 rs3853839 polymorphism between alopecia areata patients and healthy controls.

Secondary outcomes

  1. Association Between TLR7 rs3853839 Polymorphism and Disease Severity

    Time frame: Baseline

    Evaluation of the correlation between TLR7 rs3853839 genotypes and Severity of Alopecia Tool (SALT) score among alopecia areata patients.

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Association Between Toll Like Receptor- 7 Gene Polymorphism and Alopecia Areata

Acronym: TLR7-AA

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Mar 6, 2026
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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