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NCT Number: NCT07542652

Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis

The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk factor. The main questions it aims to answer include: Does the level of microplastic exposure increase the risk of gastric mucosal carcinogenesis? Can the correlation between the level of microplastic exposure and gastric mucosal carcinogenesis, as well as the sources of high - risk microplastic exposure, be explored through a questionnaire on external microplastic exposure? Researchers will complete a design structured questionnaire and ask participants to fill it out carefully and truthfully to determine whether the level of microplastic exposure increases the risk of gastric mucosal carcinogenesis.

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Key information

Conditions

Gastric Carcinoma Digestive System Diseases Digestive System Neoplasms Gastric Precancerous Lesions Gastritis Chronic Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Metaplasia Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Xijing Hosipital of Digestive Disease

Xi'an, Shaanxi, 710032, China

Location status: Recruiting

About this study

The study will categorize participants into three groups based on endoscopic and/or histopathological findings: chronic non-atrophic gastritis, precancerous lesions, and gastric cancer. Basic demographic information, *Helicobacter pylori* infection status, and plastic exposure assessment scores will be recorded for each group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 18 and 75 years old, gender is not restricted
  • Having a clear diagnosis result within the recent three months and being diagnosed with chronic non - atrophic gastritis, precancerous lesions of gastric cancer, or gastric cancer for the first time
  • Have clear Helicobacter pylori (Hp) test results
  • Be in normal mental state and able to independently complete the questionnaire survey

Exclusion criteria

  • Patients with a history of malignant tumors in other parts
  • Patients who have previously undergone upper gastrointestinal surgery, chemotherapy, or radiotherapy
  • Patients with severe diseases of major organs such as the heart, lungs liver, and kidneys
  • Patients who are currently receiving psychological intervention or taking psychiatric drugs
  • Pregnant or lactating women
  • Patients with severe missing clinical data or questionnaire information
  • Refusing to sign the informed consent form

Treatment and study plan

Primary outcomes

  1. Correlation between external exposure levels of microplastics and three pathological stages of gastric mucosal carcinogenesis

    Time frame: 9 months

    The investigators evaluated the correlation between external exposure to microplastics and the three pathological stages of gastric mucosal carcinogenesis based on the patients' final diagnosis results and the completed questionnaires they filled out.

Secondary outcomes

  1. Analysis of sources of high - risk microplastic exposure

    Time frame: 9 months

    Analyze the sources of high-risk microplastic exposure by comparing the scores of each item in the questionnaires of the three groups of participants.

  2. Synergistic toxicity of microplastics and Helicobacter pylori

    Time frame: 9 months

    Analyze whether microplastics synergistically promote gastric mucosal injury and increase the risk of canceration with Helicobacter pylori through interaction.

Study contacts

Contact information is provided by the study sponsor or research team.

Yongquan Shi

CONTACT

[email protected]

029-84771515

Sponsors and collaborators

Lead sponsor

Yongquan Shi

Other

Registry information

Official study title

Association of Microplastic Exposure With Pathological Stages of Gastric Mucosal Carcinogenesis: A Cross-Sectional Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 21, 2026
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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