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NCT Number: NCT07048548

Assessment of THL and Potential Risk of Hypothyroidism in Healthcare Workers Exposed to Low-dose Ionizing Radiation

"This study is designed to evaluate the thyroid health of healthcare workers exposed to low-dose ionizing radiation at INMOL Cancer Hospital, Lahore. Specifically, it investigates whether prolonged occupational exposure in radiology and nuclear medicine departments is associated with altered thyroid hormone levels or an increased risk of hypothyroidism. The thyroid gland is highly sensitive to radiation, and existing literature suggests a possible link between occupational exposure and thyroid dysfunction.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Hyperthyroidism Endocrine System Diseases Thyroid Diseases

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

INMOL hospital

Lahore, Punjab Province, Pakistan

About this study

A cross-sectional research design will be used over a four-month period. A sample of 44 participants will be selected using purposive sampling from the hospital's radiology and nuclear medicine staff.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Staff members from radiology and nuclear medicine departments who meet both conditions.
  • workplace experience exceeding one year
  • age between 20 to 40 will be selected for this study.

Exclusion criteria

  • Employees who have worked less than twelve months
  • pregnant participants.

Treatment and study plan

Thyroid Function Monitoring

Behavioral

This study will include healthcare professionals from the radiology and nuclear medicine departments at INMOL Cancer Hospital with at least one year of radiation exposure. A total of 44 participants will be selected through purposive sampling. Data will be collected using a structured questionnaire and blood tests for thyroid hormones (TSH, T3, T4) to assess thyroid function. Blood analysis will be conducted using CLIA or ELISA methods. The aim is to detect any association between low-dose radiation exposure and thyroid dysfunction.

Primary outcomes

  1. thyroid function assessment

    Time frame: 12 Months

    Thyroid function is assessed through blood tests, primarily measuring TSH (Thyroid Stimulating Hormone), T4 (Thyroxine), and sometimes T3 (Triiodothyronine) levels. Abnormal levels of these hormones can indicate an underactive (hypothyroidism) or overactive (hyperthyroidism) thyroid.

    Normal Ranges (approximate):

    TSH: 0.4 - 4.0 mIU/L Free T4: 0.7 - 1.9 ng/dL Total T4: 5.0 - 12.0 μg/dL Total T3: 80 - 220 ng/dL

Sponsors and collaborators

Lead sponsor

Superior University

Other

Registry information

Official study title

Assessment of Thyroid Hormone Levels and Potential Risk of Hypothyroidism in Healthcare Workers Exposed to Low-dose Ionizing Radiation

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jul 2, 2025
Registry last updated
Jul 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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