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OpenTrials
Completed

NCT Number: NCT02638844

Assessment of Right Ventricular 2d-strain in Acute Respiratory Distress Syndrome

Assessment of right ventricular (RV) function in patients with acute respiratory syndrome (ARDS) is warranted because RV failure is frequent and associated with worse outcome. Transthoracic echocardiography is the cornerstone of RV assessment but it remains challenging. Quantification of RV deformation by speckle-tracking imaging echocardiography (STE) is a widely available and reproducible technique that readily provides an integrated analysis of all segments of the RV. This study aims to investigate the accuracy of STE-derived strain parameters in assessing RV function during ARDS.

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Key information

Conditions

ARDS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lemarie Jeremie

Nancy, 54000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with moderate or severe ARDS (Berlin definition)
  • receiving mechanical ventilation (>48h estimated length)
  • Transthoracic echocardiography performed during the first 36h after ICU admission

Exclusion criteria

  • pregnancy
  • protected or deprived of Liberty major
  • chronic respiratory disease
  • history of clinical right heart failure
  • chronic heart failure with LVEF < 35%
  • severe valvular heart disease
  • under 18 or protected-adults

Treatment and study plan

Primary outcomes

  1. Measure of longitudinal peak systolic strain

    Time frame: up to 36 hours after Intensive Care Unit admission

Secondary outcomes

  1. Measure of PaO2/FiO2 ratio

    Time frame: up to 36 hours after Intensive Care Unit admission

  2. Ventilator-free days

    Time frame: 28 days

  3. Mortality

    Time frame: 28 days

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

ARDStrain : Assessment of Right Ventricular 2d-strain in Acute Respiratory Distress Syndrome

Acronym: ARDStrain

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Dec 23, 2015
Registry last updated
Feb 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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