Assessment of Renal Function in Cirrhotic Patients

The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.

Completed

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Key information

Conditions

Liver Failure Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hepatic Insufficiency Kidney Diseases Liver Diseases Male Urogenital Diseases Renal Failure Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Baylor All Saint's Medical Center in Fort Worth

Fort Worth, Texas, 76104, United States

About this study

Serum cystatin C, creatinine clearance based calculations, and 125I-Iothalamate clearance (Glofil) will be obtained in 220 patients with cirrhosis. Utilizing this information, the correlation between cystatin C and 125I-Iothalamate clearance will be obtained. In addition, the current serum creatinine based calculations and true creatinine clearance will also be correlated with 125I-Iothalamate clearance. The results of this study should help to determine whether serum cystatin C is a more sensitive laboratory measurement of renal function in patients with cirrhosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

over 18 undergoing evaluation for a liver transplant

Exclusion criteria

known allergy or sensitivity to 125I-Iothalamate

Treatment and study plan

Primary outcomes

Creatinine based blood and urine laboratory tests as a measure of renal function in patients with chirrosis of the liver.

Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Baylor Research Institute

Other

Registry information

Official study title

Assessment of Renal Function in Cirrhotic Patients -A Comparison of Cystatin C and Creatinine Based Calculations to 125I-iothalamate

Important dates

Study start: 2010
Primary completion: 2021
Study completion: 2025
First posted: Jul 10, 2013
Registry last updated: Oct 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed