Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically. Therefore, the major goal in the intensive care unit is to prevent the occurrence of multiple organ failure. The sepsis protocol and early goal directed treatment have great effects to reduce development of multiple organ failure and to decrease the mortality rate. However, sometime the condition of patient deteriorated in spite of both the mean blood pressure and mixed venous oxygen saturation are normal. Some experts recognize that there might be microcirculatory dysfunction of tissue or organ. The dysfunction of microcirculation might due to vasoconstriction or microthrombosis. Vasoconstriction might result from systemic inflammation, reactive oxygen species, or dysfunction of synthesis of NO (nitric oxide). Microthrombosis might result from systemic inflammation, reactive oxygen species, imbalance of coagulatory system, or damage of endothelial cell.

In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. This study tries to investigate the relation between oxidative stress and microcirculation. Furthermore, the investigators will try to investigate the correlation between the severity of oxidative stress and microcirculatory dysfunction and the severity of disease and prognosis. The investigators hope this study will help them to figure out the picture of disease progression of patients. It may conduct further study to modulate the oxidative stress, to improve the microcirculatory function, and finally to improve the outcome of patients.

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Key information

Conditions

Sepsis ARDS Brain Death Brain Diseases Central Nervous System Diseases Coma Consciousness Disorders Death Digestive System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hepatic Insufficiency Infections Inflammation Kidney Diseases Liver Diseases Liver Failure Male Urogenital Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Failure Renal Insufficiency Systemic Inflammatory Response Syndrome Unconsciousness Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Taiwan University Hospital

Taipei, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

> 18 y/o
Related diagnosis made within 24h
Group 1 - Sepsis
Group 2 - Postoperative care
Group 3 - ARDS
Group 4 - Renal failure
Group 5 - Liver failure
Group 6 - Brain death

Exclusion criteria

Pregnant patients
Related diagnosis made longer than 24h
Patients who have received antioxidants within 24h
Patients who have received hyperbaric oxygen therapy
Patients who have a hemoglobin value less than 9 g/dl
Patients who have received NO

Treatment and study plan

Critical Care

Other

Standard care for each group of patients

Primary outcomes

Mortality Severity of Organ Failure

Time frame: 28 days

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Microcirculation and Oxidative Stress in Critically Ill Patients in Surgical Intensive Care Unit

Important dates

Study start: 2007
Primary completion: 2010
Study completion: 2011
First posted: Dec 16, 2008
Registry last updated: Jan 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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