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NCT Number: NCT06723431

Assessment of Pre Hospital Rescue Intervention for Seizure in Pediatric Patients

1. Evaluation of pre hospital rescue intervention of seizure management. 2. To investigate the type of rescue medication, Efficacy, route of administration, Side effects of this drug, frequency and Indication of its use.

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Key information

Age range

2 year–18 year

Sex eligibility

All sexes

Study type

Observational

About this study

An epileptic seizure is a transient occurrence with signs or symptoms due to abnormal excessive and synchronous neuronal activity in the brain.

There are many different types of seizures:

Current classification designates two large categories - partial or generalized. In a partial seizure, one area of the cortex is thought to be activated initially and may show simple symptoms such as a motor or sensory phenomena.

Partial seizures may rapidly secondarily generalize and spread to involve all cortical areas.

Generalized seizures result from diffuse cortical activation at seizure onset . Seizure cluster provides an opportunity to administer prompt treatment.

Delays in the treatment of seizure emergencies are often associated with negative patient outcomes.

Seizure clusters become less responsive to treatment when they continue unabated over time .

In addition to using anti epileptic medications, the treatment of seizures aims at correcting any identifiable causative process. Care is needed to prevent any secondary brain injury, which may include advanced respiratory and cardiovascular support. Monitoring is necessary to detect hypotension and hypoxia and steps taken to correct those conditions when recognized. Common complications may include traumatic injuries such as tongue lacerations or scalp lacerations . Convulsive status epileptic leads to brain damage on the cellular level and may itself be epileptogenic. Transformed or subtle generalized convulsive status epileptic or non convulsive seizures detected by EEG monitoring in critically ill patients may also contribute to brain laceration .

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with recurrent attack of seizure and with prolonged seizure with prescribed treatment at home.
  • Patients aged from 2 years to 18 years

Exclusion criteria

  • First attack of seizure
  • condition mimic epilepsy

Treatment and study plan

Primary outcomes

  1. Aim of the study

    Time frame: Baseline

    • Evaluation of prehospital rescue intervention of seizure management.
    • To investigate the type of rescue medication,
    • it's Efficacy.
    • it's route of administration.
    • Side effects of this drug.
    • frequency .
    • Indication of it's use.

Secondary outcomes

  1. Seizure triggers

    Time frame: Baseline

    Seizures can be triggered by things in the environment. Seizure triggers don't cause epilepsy, but they may trigger seizures in people who have epilepsy.

    Most people with epilepsy don't have reliable triggers that always cause a seizure. However, they often can identify factors that make it easier to have a seizure. Possible :seizure triggers include

    • Illness
    • Skipping doses of antiseizure medicines or taking more than prescribed.
    • Dehydration
    • Lack of sleep
    • Flashing lights
    • Stress
    • Hormone changes during the menstrual cycle• Illicit drug use
    • Skipped meals

Study contacts

Contact information is provided by the study sponsor or research team.

Fatma abdelfatah ali

CONTACT

0 1006347038

Samah Gamal Hussien, doctor

CONTACT

[email protected]

+201025389433 ext. +201023852301

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Dec 9, 2024
Registry last updated
Dec 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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