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Completed

NCT Number: NCT06924892

Assessment of Music Experiences in Navigating Depression

The study team sought to scientifically investigate strategic subsets of depressed individuals or people prone to or at-risk of depression through music experiences of individual, group, and blended supported contexts. Meetings with the study multi-disciplinary team, included member of the Carnegie Hall Weill Music Institute and University affiliates, where the study team gathered quantitative and qualitative data in individual and group forums, measuring disease process and levels of participation. Through tabulation of participatory options with standardized depression and resilience measurements, the study team studied how live music could alter depressive symptoms over time and/ or change negative influencers of mood, shift quality of life, and lead toward possibly enhanced disease trajectory outcomes.

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Key information

Conditions

Depression Anxiety Disorders Behavior Behavioral Symptoms Mental Disorders

Age range

8 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mount Sinai Union Square

New York, 10003, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Participants between the ages of 8-70 years with a clinical diagnosis of Major Depressive Disorder (MOD) who met the DSM-5 (2013) criteria for a Major Depressive Episode, and/or who identify themselves, or are identified by family, or referring clinicians as depressed, or are prone to depression
  • Depressive episodes and/or showing symptoms of mild to moderate depression intensity
  • Self-reported satisfactory bilateral hearing
  • English or Spanish language fluency sufficient to complete the interviews and questionnaires

Exclusion criteria

  • Axis I diagnosis, aside from MOD, considered the primary diagnosis
  • Bipolar Disorder Type I or II,
  • Axis II diagnosis such as antisocial or borderline.
  • Arrhythmia,
  • Pacemaker
  • Prolapsed vertebral disc, and
  • Recent back or neck injuries.

Treatment and study plan

Music Therapy

Behavioral

Independent music therapy 45-minute sessions provided weekly for 3 months

Other names: Music

Wellness Concerts

Other

Wellness Concerts provided at partner sites (Carnegie Hall Weill Music Institute, Cooper Union College, Third Street Music Settlement).

Primary outcomes

  1. Connor-Davidson Resilience Scale (CD-RISC)

    Time frame: end of study at 3 months

    The Connor-Davidson Resilience Scale (CD-RISC) measures inherent resiliency. The 10-item instrument has high internal consistency. Each item consists of a 5-point Likert scale (scored from zero to four). Ranging from 0-40 with higher scores reflecting greater perceived resilience.

  2. The Beck Depression Inventory Second Edition (BDI-II) score

    Time frame: end of study at 3 months

    The Beck Depression Inventory Second Edition (BDI-II) is a multiple-choice self-report inventory that assesses severity of depression. The BDI-II contains 21 items on a 4-point scale from 0 (symptom absent) to 3 (severe symptoms). The minimum score is 0 and the maximum score is 63, with a higher score indicating more severe depressive symptoms.

  3. Child Depression Inventory

    Time frame: end of study at 3 months

    The total score range 0 to 54 which is converted to a T-Score, higher score indicates more symptoms.

Sponsors and collaborators

Lead sponsor

Icahn School of Medicine at Mount Sinai

Other

Collaborators

  • Carnegie Hall Weill Music Institute
  • Cooper Union College
  • Third Street Music Settlement

Registry information

Official study title

Assessment of Music Experiences in Navigating Depression (AMEND)

Acronym: AMEND

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Apr 11, 2025
Registry last updated
Oct 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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