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NCT Number: NCT03853135

Assessment of Endocan Serum Levels in Patients With Behcet Disease

The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.

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Key information

Conditions

Behçet Behcet Syndrome Cardiovascular Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Eye Diseases Genetic Diseases, Inborn Hereditary Autoinflammatory Diseases Mouth Diseases Panuveitis Skin Diseases Skin Diseases, Genetic Skin Diseases, Vascular Skin and Connective Tissue Diseases Stomatognathic Diseases Uveal Diseases Uveitis Uveitis, Anterior Vascular Diseases Vasculitis

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Benha University Hospital

Banhā, Qalyubia Governorate, 13518, Egypt

About this study

This study will be carried out on two groups:

  • Group (I): Forty two patients diagnosed to have Behcets disease fulfilling the International Criteria for BD .

Group (II): including 42 age and sex matching healthy volunteers as control group.

(A) Clinical evaluation

  • Complete history taking.
  • Thorough clinical examination including opthalmologic evaluation .
  • Disease activity using The Behcet's disease current activity form (BD-DAF) . (B) Laboratory assessment:

All patients will be subjected to the following measurements:

  • ESR
  • CRP
  • CBC
  • liver and kidney function tests

d) Serum Endocan level e)triglycrides f) cholestrol C) carotid intima media thickness

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with Behcets disease fulfilling the International Criteria for BD .

Exclusion criteria

  • infection
  • malignancy
  • other connective tissue disease
  • chronic liver disease
  • chronic kidney disease
  • Diabetes mellitus
  • hypertension
  • hyperlipidemia

Treatment and study plan

measurement of serum endocan

Diagnostic Test

measurement of serum levels of endocan

Other names: endothelial cell-specific molecule 1

Primary outcomes

  1. the Behcet's disease current activity form (BDCAF)

    Time frame: : through study completion, an average of 6 months

    One point is given to the presence of different organ involvement over the 4 weeks prior to assessment as follows: headache, mouth ulcers, genital ulcers, skin lesions , joint involvement , gastrointestinal symptoms , eye involvement , nervous system involvement , and major vessel involvement.The total score will be out of 12 and higher score indicates worse outcome. we will assess the relation between serum endocan level and BDCAF

  2. Erythrocyte sedimentation rate (ESR)

    Time frame: : through study completion, an average of 6 months

    ESR measured in mm/1st hour by westergren method. we will assess the relation between serum endocan level and ESR

  3. C reactive protein (CRP)

    Time frame: : through study completion, an average of 6 months

    CRP measured in mg/L using nephlometry. we will assess the relation between serum endocan level and CRP

  4. carotid intima media thickness

    Time frame: : through study completion, an average of 6 months

    Color Doppler ultrasonography was performed for both common carotid arteries in a longitudinal orientation and measured with millimeter

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Assessment of Endocan Serum Levels in Patients With Behcet Disease: Relation to Clinical Parameters and Disease Status

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Feb 25, 2019
Registry last updated
Jan 6, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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