Assessing Granulomatosis With Polyangiitis Activity: 18F-FDG PET/CT vs BVAS v3

The goal of this observational study is to quantify activity and extent of disease in patients with GPA using 18F-FDG PET/CT. The main questions it aims to answer are:

Sensitivity of 18 F-FDG PET/CT in patients with GPA? Correlation of 18F-FDG PET/CT semi-quantitative parameters with BVAS v3?

Completed

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Key information

Conditions

Granulomatosis With Polyangiitis (Wegener's) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Autoimmune Diseases Cardiovascular Diseases Granulomatosis with Polyangiitis Immune System Diseases Lung Diseases Lung Diseases, Interstitial Respiratory Tract Diseases Skin Diseases Skin Diseases, Vascular Skin and Connective Tissue Diseases Systemic Vasculitis Vascular Diseases Vasculitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh

Chandigarh, 160012, India

About this study

Patients age more than 18 with active GPA were recruited and 18F-FDG PET/CT was done after clinical assessment and evaluation. BVAS v3 score was calculated and then patients underwent 18F-FDG PET/CT. Findings of the scans were evaluated by expert nuclear medicine physicians and various semiquantitative parameters were calculated. Sensitivity was then calculated and correlation of BVAS v3 score was done with the calculated semiquantitative parameters.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with newly diagnosed or relapsed active GPA, Age more than or equal to18 years.

Exclusion criteria

Pregnant/ lactating women and non-consenting adults

Treatment and study plan

18F-FDG

Drug

18 F-FDG PET/CT was done for patients with active GPA

18F-FDG PET/CT

Device

Use of 18F-FDG PET/CT scan in patients with active GPA

Primary outcomes

Per-patient sensitivity of 18F-FDG PET/CT for detection of clinically active GPA and correlation of 18 F-FDG PET/CT semiquantitative parameters with BVAS v3

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Post Graduate Institute of Medical Education and Research, Chandigarh

Other

Registry information

Official study title

Assessment of Disease Activity in Patients With Granulomatosis With Polyangiitis Using 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography and Its Correlation With Birmingham Vasculitis Activity Score Version 3

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jul 17, 2026
Registry last updated: Jul 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed