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Completed

NCT Number: NCT07269522

Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.

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Key information

Conditions

Anterior Cruciate Ligament Injury Anterior Cruciate Ligament Injuries Knee Injuries Leg Injuries Wounds and Injuries

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lahore General Hospital

Lahore, Punjab Province, 54000, Pakistan

About this study

In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any gender
  • Aged 18-40 years
  • With clinically and radiologically confirmed arthroscopic evidence of ACL injury

Exclusion criteria

  • With comprised bilateral ACL tears
  • Lack of fitness due to associated comorbidity
  • Fractures of lower limb bones and/or spine/neurovascular injuries
  • Injuries to other knee ligaments
  • Significant knee joint arthritis
  • Local skin infections

Treatment and study plan

ACL reconstruction by hamstring graft with PRP

Procedure

Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

ACL reconstruction by hamstring graft

Procedure

Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Primary outcomes

  1. Anterior Drawer's test

    Time frame: 12 weeks

    Number of patients having grade-1 on the Anterior Drawer's test

  2. Lachman's test

    Time frame: 12 weeks

    Number of patients having grade-1 on the Lysholm knee score

  3. Lysholm knee score

    Time frame: 12 weeks

    A higher Lysholm knee score was labeled as effectiveness of the treatment.

Sponsors and collaborators

Lead sponsor

Muhammad Aamir Latif

Other

Registry information

Official study title

Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Dec 8, 2025
Registry last updated
Dec 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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