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OpenTrials
Completed

NCT Number: NCT01862146

Arterial Remodeling in Smokers

Cigarette smoking is the most important modifiable cardiovascular risk factor leading to endothelial dysfunction and was suggested to impair arterial regeneration.The aim of the study was to investigate the effect of smoking on vascular response to transradial coronary angiography (TCA).

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Key information

Conditions

FMD Behavior IMT Smoking

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Division of Cardiology, Pulmonology and Vascular Medicine Duesseldorf,

Düsseldorf, North Rhine-Westphalia, 40225, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all subjects underwent a TCA

Exclusion criteria

  • acute inflammation cardiac arrhythmia renal failure heart failure (NYHA II-IV) CRP > 1 mg/dl malignant disease

Treatment and study plan

smoke expose

Procedure

Primary outcomes

  1. IMT hyperplasia

    Time frame: change in radials IMT after 6-14 month after a TCA

    IMT is measured by high resolution ultrasound in the radial arteries.

Secondary outcomes

  1. Endothelial function

    Time frame: change in flow mediated dilatation after 10-14 months

    Flow mediated dilatation (FMD)

Other outcomes

  1. cell migration

    Time frame: baseline

    measured by boyden chamber from blood plasma

  2. Regeneration

    Time frame: baseline

    measured by scratch assay

Sponsors and collaborators

Lead sponsor

Klinik für Kardiologie, Pneumologie und Angiologie

Other

Registry information

Official study title

Response-to-injury in Patients Undergoing Transradial Coronary Angiography: Arterial Remodeling in Smokers

Acronym: TCA

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
May 24, 2013
Registry last updated
Jun 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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