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OpenTrials
Completed

NCT Number: NCT02127333

Role of Oxygen for Vascular Dysfunction

Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.

Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.

We hypothesize that hypoxemia leads to impaired vascular function.

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Key information

Conditions

Endothelial Dysfunction Arterial Occlusive Diseases Arteriosclerosis Carbon Dioxide Pressure Cardiovascular Diseases Chronic Disease Coronary Artery Disease Coronary Disease Disease Attributes FMD Forced Expiratory Volume After 1 Second Heart Diseases IMT Lung Diseases Lung Diseases, Obstructive Microcirculation Myocardial Ischemia Oxygen Pressure Oxygen Saturation Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Vascular Diseases

Age range

40 year–80 year

Sex eligibility

Male

Study type

Observational

Primary location

Division of Cardiology, Pulmonary Disease and Vascular Medicine

Düsseldorf, 40225, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • stable coronary artery disease
  • stable chronic obstructive pulmonary disease

Exclusion criteria

  • acute myocardial infarction within 30 days
  • acute exacerbated COPD within 30 days
  • acute infections
  • severe acute or chronic renal failure
  • severe heart failure
  • atrial fibrillation
  • severe cardiac arrhythmia
  • hypotension
  • active malignant disease
  • active rheumatic disease
  • pulmonary hypertension with vasoactive therapy

Treatment and study plan

Primary outcomes

  1. Flow-mediated dilation of the brachial artery

    Time frame: Baseline

Secondary outcomes

  1. Forearm blood flow

    Time frame: Baseline

  2. Laser doppler perfusion

    Time frame: Baseline

  3. Intima-media thickness of the brachial artery

    Time frame: Baseline

  4. Fractional diameter change of the brachial artery

    Time frame: Baseline

  5. Endothelium-independent vasodilation of the brachial artery

    Time frame: Baseline

Other outcomes

  1. Plasma nitrite concentration

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Klinik für Kardiologie, Pneumologie und Angiologie

Other

Registry information

Official study title

Role of Acute and Chronic Hypoxemia for Vascular Function

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Apr 30, 2014
Registry last updated
Dec 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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