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NCT Number: NCT07281885

Aromatherapy in Reducing PONV for Total Joint Replacement Patients

This study investigates the effectiveness of aromatherapy in reducing postoperative nausea and vomiting (PONV) among patients undergoing total joint replacement surgery, as these complications can lead to patient discomfort and prolonged recovery. It is designed as a randomized controlled trial involving 159 participants, who will be divided into three groups: an intervention group receiving aromatherapy patches (lavender-sandalwood or orange-ginger) plus standard care, a placebo group with a placebo patch plus standard care, and a control group receiving standard care alone. PONV will be measured using the Rhodes Index of Nausea, Vomiting, and Retching (RINVR) at baseline, 30 minutes after the intervention, and every 12 hours post-surgery. Additionally, patient satisfaction will be assessed through a 5-point Likert scale survey. The primary outcome of the study is the evaluation of RINVR scores, while the secondary outcome focuses on patient satisfaction levels. Data will be statistically analyzed using two-way ANOVA for repeated measures, with a significance level defined as p < 0.05. The study aims to determine the viability of aromatherapy as a complementary treatment for PONV, potentially improving postoperative care, enhancing patient satisfaction, and offering a cost-effective alternative to conventional anti emetic treatments if proven effective.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hong Kong Buddhist Hospital

Wong Tai Sin, Hong Kong

Location status: Recruiting

Location contact

Choi Wan CHAN, APN (NURSING)

CONTACT

[email protected]

852-2339 ext. 6266

Claudia Fuk Chi Cheng, RN (NURSING)

SUB_INVESTIGATOR

Ka Wai Fiona Mak, WM (NURSING)

SUB_INVESTIGATOR

Ka Wun Sit, APN (NURSING)

SUB_INVESTIGATOR

Kwan Yi Lew, RN (NURSING)

SUB_INVESTIGATOR

Victor Cheng, EOII(MDSSC)

SUB_INVESTIGATOR

Wing Sze Tse, RN (NURSING)

SUB_INVESTIGATOR

Yat Hung Lee, RN (NURSING)

SUB_INVESTIGATOR

Yuk Chun Lai, RN (NURSING)

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 or above
  • Patients scheduled for total joint replacement surgery at the HKBH

Exclusion criteria

  • Cognitive impairments
  • Allergy to lavender, orange, ginger, or sandalwood
  • Allergy to micro-pore tape
  • Allergy to opioid medication
  • Undergoing other therapeutic treatment for PONV control, except prescribed medications

Treatment and study plan

Aromatherapy patches

Other

Applying aromatherapy patch served as intervention part in addition to standard care. Aromatherapy patch will be attached to the inner side of of the patient's top covered by a plain gauze with micro-pore tape.

Other names: Lavender-Sandalwood patch, Orange-Ginger patch

Placebo Patches

Other

On top of standard care. Placebo patch, which looks like the aromatherapy patch but contains no element of any essential oil, will be attached to the inner side of of the patient's top covered by a plain gauze with micro-pore tape.

Control (Standard treatment)

Drug

Prescribed antiemetic treatment

Primary outcomes

  1. Postoperative Nausea and Vomiting

    Time frame: Through study completion, an average of 24 hours at 4 timepoints: T0 (baseline at PACU), T1 (up to 30 minutes from applying intervention to reassessment at PACU), T2 (up to 12-hour post-intervention in ward), T3 (up to 24-hour post-intervention in ward).

    as measured by Rhodes Index of Nausea, Vomiting, and Retching, which consists of 8-item 4-point Likert-scales for nausea, vomiting, and retching symptoms with a total score ranging from 0 to 32 for each time point. The higher scores indicate the higher severity of nausea, vomiting, and retching experienced by the patient.

Secondary outcomes

  1. Patient Satisfaction

    Time frame: Through study completion, an average of 24 hours at 4 timepoints: T0 (baseline at PACU), T1 (up to 30 minutes from applying intervention to reassessment at PACU), T2 (up to 12-hour post-intervention in ward), T3 (up to 24-hour post-intervention in ward).

    Use of patient satisfaction survey which consists of 2-item 5-point Likert scales to address the extent to which intervention could be effective in discomfort relief and control perceived by patients. The total score of the survey ranged from 2 to 10; the higher the score the more likely patients showed agreement on treatment effectiveness in discomfort relief and control.

Study contacts

Contact information is provided by the study sponsor or research team.

Choi Wan CHAN, APN (NURSING)

CONTACT

[email protected]

852-2339 ext. 6266

Victor CHEUNG, EOII(MDSSC)

CONTACT

[email protected]

852-3506 ext. 8773

Sponsors and collaborators

Lead sponsor

Hong Kong Buddhist Hospital

Other

Collaborators

  • Queen Elizabeth Hospital, Hong Kong

Registry information

Official study title

A Randomized Control Trial on the Efficacy of Aromatherapy in Reducing Postoperative Nausea and Vomiting in Total Joint Replacement Patients

Acronym: RCT PONV

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 15, 2025
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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