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OpenTrials
Completed

NCT Number: NCT06779292

Application of Large Language Models in Emergency Neurology

Emergency neurology covers a wide range of conditions, often involving urgent situations such as acute cerebrovascular diseases, seizures, central nervous system infections, and consciousness disorders. However, due to the time constraints in emergency care and limited patient information collection, misdiagnosis and missed diagnoses are common issues. Large language models (LLMs) possess powerful natural language processing and knowledge reasoning capabilities, enabling them to directly handle and understand complex, unstructured medical data such as patient medical records, dialogue notes, and laboratory test results. LLMs show broad potential for application in complex medical scenarios. This study aims to evaluate the application value of LLMs in emergency neurology, specifically examining their diagnostic accuracy in emergency neurology conditions, analyzing the feasibility of treatment plans and further examination recommendations proposed by the model, and exploring their potential in improving diagnostic efficiency and aiding decision-making.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Xuanwu Hospital, Capital Medical University

Beijing, Beijing Municipality, 100053, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18-80 years, male or female.
  • Patients seeking emergency neurology care.
  • Patients who can provide complete medical records (including consultation recordings, physical examination, test results, etc.).
  • Voluntary participation and signing of informed consent.

Exclusion criteria

  • Patients who directly enter the resuscitation process due to the severity of their condition(e.g., patients who are immediately placed in the ICU).
  • Patients with unstable vital signs.
  • Patients who are unable to communicate effectively (e.g., severe consciousness impairment or severe cognitive disorders).
  • Patients who are currently participating in other clinical trials.

Treatment and study plan

Large Language Model Diagnosis

Diagnostic Test

Using the large language model for diagnosing emergency neurology conditions.

Primary outcomes

  1. dignostic accuracy

    Time frame: 1 month

    To evaluate the consistency between the diagnosis made by large language models for emergency patients and the confirmed diagnosis after inpatient or outpatient visits.

Secondary outcomes

  1. Feasibility of treatment plans

    Time frame: 1 month

    Experts use the Emergency Treatment Recommendation Scoring Scale to evaluate the treatment suggestions from conventional methods and large language models. The maximum score is 5 and the minimum score is 1, with 5 representing strong agreement with the recommendation.

  2. dignostic specificity

    Time frame: 1 month

    A comparison of dianostic specificity between large language model diagnosis and emergency department physicians diagnosis

  3. Diagnostic Sensitivity

    Time frame: 1 month

    A comparison of dianostic sensitivity between large language model diagnosis and emergency department physicians diagnosis.

  4. False Discovery Rate

    Time frame: 1 month

    A comparison of the false discovery rate between large language model diagnosis and emergency department physicians diagnosis.

Sponsors and collaborators

Lead sponsor

Capital Medical University

Other

Registry information

Official study title

Application of Multimodal Large Language Models in Emergency Neurology Diagnosis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 16, 2025
Registry last updated
Apr 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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