Apoptic Biomarkers of Periodontal Disease

The goal of this study is to facilitate early diagnosis of gum disease. Proteins associated with cell death will be isolated from gum pockets of diseased and healthy patients and evaluated.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Michigan Center for Oral Health Research

Ann Arbor, Michigan, 48106, United States

About this study

Early detection of the progression of periodontitis is difficult because it typically relies on comparisons of clinical measurements made with a calibrated probe and nonstandardized radiographs over time. Both methods detect periodontal breakdown only after it has occurred. Therefore, considerable emphasis has been placed on identifying more specific and sensitive methods to diagnose and detect periodontal disease progression. The overall goal of this project is to determine whether specific apoptosis-associated proteins, specifically fibronectin (FN) fragments, caspase-3, soluble Fas, and soluble Fas ligand, sampled from gingival crevicular fluid (GCF) can be used as markers for periodontal disease progression.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults over age of 18
Healthy or diagnosis of periodontitis

Exclusion criteria

Active treatment with anti-inflammatory agents such as NSAIDs or steroids and pregnant females

Treatment and study plan

collection of gingival crevicular fluid

Other

GCF samples will be collected at 3 month intervals

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Official study title

Apoptotic Biomarkers of Periodontal Disease

Important dates

Study start: 2006
Primary completion: 2009
Study completion: 2009
First posted: Dec 6, 2007
Registry last updated: May 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed