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Completed

NCT Number: NCT05655338

Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis)

Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

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Key information

Conditions

Aggressive Periodontitis Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year–38 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Background: Treatment of aggressive periodontitis (stage III, grade C periodontitis) represents a big challenge. The aim of the study was to compare the long-term results of antimicrobial photodynamic therapy (aPDT) and antibiotic therapy as an adjunct to conventional non-surgical therapy in patients with aggressive periodontitis. Materials and methods: Twenty subjects with untreated aggressive periodontitis (stage III, grade C periodontitis) were divided into two groups: the test group (TG) received non-surgical therapy and two sessions of aPDT using a laser (HELBO TheraLite laser) with a wavelength of 670nm associated with HELBO Blue photosensitizer, and the control group (CG) received non-surgical therapy and antibiotics (amoxicillin 500mg and metronidazole 400mg, 7 days). Clinical parameters of probing depth, clinical attachment level and bleeding on probing (BOP) were assessed at baseline, 3, 6, 9 and 12 months after treatment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aggressive periodontitis (stage III, grade C periodontitis)
  • nonsmokers
  • at least 20 teeth in oral cavity
  • systemically healthy

Exclusion criteria

  • any previous periodontal treatment
  • smoking
  • pregnancy
  • ingestion of systemic antibiotics within three months before therapy

Treatment and study plan

Antimicrobial Photodynamic therapy

Device

Other names: HELBO TheraLite Laser

Systemic Antibiotics

Drug

Other names: Amoxicillin (Hiconcil), Metronidazole (Efloran)

Primary outcomes

  1. Probing depth reduction

    Time frame: 3 months

    Change in probing depth

  2. Bleeding on probing

    Time frame: 3 months

    Bleeding after measurement of probing depth

Secondary outcomes

  1. Clinical attachment loss

    Time frame: 3 months

    Change in clinical attachment

Sponsors and collaborators

Lead sponsor

University of Ljubljana

Other

Registry information

Official study title

Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis (Stage III, Grade C Periodontitis): A Comparison Between Photodynamic Therapy and Antibiotic Therapy as an Adjunct to Non-Surgical Periodontal Treatment

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Dec 19, 2022
Registry last updated
Dec 19, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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