Skip to main content
OpenTrials
Completed

NCT Number: NCT01246596

Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis

The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Chronic Periodontitis Aggressive Periodontitis Chronic Disease Disease Attributes Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Presence / Absence of EBV Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dr Severine VINCENT

Nice, 0600, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 10 patients affected by chronic periodontitis
  • 10 patients affected by aggressive periodontitis
  • 10 healthy patients (orthodontics extraction)
  • Subject who have read and understood the information note relative under investigation and who have signed the informed consent
  • major patient

Exclusion criteria

  • Patient with no contre-indication to periodontal treatment
  • Patient with serious blood disease
  • Patient who exhibits systemic condition incompatible with realization of the study
  • Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
  • Patient who presents a buccal carcinoma treated with radiotherapy
  • Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
  • Patient who presents a linguistic or psychic incapacity to understand information

Treatment and study plan

dental root planing

Procedure

The objective of root planing, otherwise known as conventional periodontal therapy, non-surgical periodontal therapy, or dental prophylaxis is to remove or eliminate the etiologic agents which cause inflammation: dental plaque, its products and calculus,[1] thus helping to establish a periodontium that is free of disease.[2]

Primary outcomes

  1. Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization)

    Time frame: at time=0

Secondary outcomes

  1. Epithelial tissue infected by EBV (by immunofluorescence and in situ hybridization)

    Time frame: at time = 0

  2. Presence / absence of latency and / or lytic proteins (by immunofluorescence and in situ hybridization)

    Time frame: at time = 0

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Nov 23, 2010
Registry last updated
Nov 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.