Skip to main content
OpenTrials
Completed

NCT Number: NCT00646126

Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission

The malaria parasite Plasmodium falciparum remains at sub-patent level throughout the dry season in areas of seasonal malaria transmission. Targeting this parasite reservoir before the transmission season could be a good strategy for malaria control. We are conducting a randomized double blind placebo controlled mass drug administration trial in eight village to clear the dry season low level parasitaemia with an ultimate aim of controlling malaria in eastern Sudan.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Plasmodium Falciparum Asymptomatic Parataemia Infections Malaria Malaria, Falciparum Mosquito-Borne Diseases Parasitic Diseases Protozoan Infections Sub Patent Parasitaemia Vector Borne Diseases

Age range

1 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Tropical Medicine Research Institute

Khartoum, Khartoum State, 11111, Sudan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All residents of the 8 villages

Exclusion criteria

  • Pregnancy
  • History of allergy to sulfa drugs

Treatment and study plan

Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS)

Drug

Standard three day regimen

placebo tablet similar to active drug in shape and size

Drug

Dosage similar to active drug(standard three days regimen)

Primary outcomes

  1. Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages

    Time frame: October to December 2006

Secondary outcomes

  1. 1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes

Sponsors and collaborators

Lead sponsor

Tropical Medicine Research Institute

Other

Collaborators

  • International Atomic Energy Agency
  • London School of Hygiene and Tropical Medicine

Registry information

Official study title

Validation of the Use of Istope-Based Molecular Techniques for Malaria Control

Important dates

Study start
2005
First posted
Mar 28, 2008
Registry last updated
Mar 28, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.