Clinical Practices for Treating Severe Malaria Caused by P. Falciparum

This study looks at how doctors in three hospitals in France treat patients with a serious form of malaria caused by Plasmodium falciparum. It focuses on cases where the level of malaria parasites in the blood is 4% or higher. The study will compare how often a type of medicine called ACT (artemisinin-based combination therapy) is used on its own instead of the usual first-choice treatment (intravenous artesunate), and whether ACT works just as well. It will also check how well patients recover, whether they have complications, and how long they stay in the hospital.

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Key information

Conditions

Malaria, Falciparum Antimalarials Artemisinins Drug Therapy, Combination Hospitalization Infections Malaria Mosquito-Borne Diseases Parasitic Diseases Plasmodium Falciparum Protozoan Infections Retrospective Studies Treatment Outcome Vector Borne Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

France

Saint-Denis, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients aged 18 years or older.
Diagnosis of Plasmodium falciparum malaria with a parasitemia level ≥ 4%.

Exclusion criteria

Patients under 18 years old

Treatment and study plan

Primary outcomes

Proportion of patients treated with artemisinin-based combination therapy (ACT) alone for Plasmodium falciparum malaria with parasitemia ≥4%.

Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Centre Hospitalier de Saint-Denis

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Jun 18, 2025
Registry last updated: Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed