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OpenTrials
Completed

NCT Number: NCT04768829

Antifungal Potential of Moringa Olifera Against Otomycosis

patients with Otomycosis were recognized by an ENT specialist. 20 patients were distributed randomly into two groups. The first group will be treated with Nystatin ear drops twice daily. The second group will be treated with Moringa ear drops. patients will be examined endoscopically by the ENT specialist. patient's swabs will be isolated and analyzed by ELISA.

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Key information

Conditions

Otomycosis Bacterial Infections and Mycoses Ear Diseases Infections Mycoses Otorhinolaryngologic Diseases

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Soad A. Mohamad

Minya, Minya Governorate, 05673, Egypt

About this study

Inclusion criteria

(1) Otomycosis .

Exclusion criteria

  • tympanic membrane perforation;
  • concurrent immune suppression,
  • and concurrent bacterial infection.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Otomycosis
  • ear inflammation

Exclusion criteria

  • tympanic membrane perforation
  • concurrent immune suppression,
  • concurrent bacterial infection.

Treatment and study plan

Moringa oleifera leaf 10mg/100ml

Drug

ear drops

Other names: ear drops

Ear Drop

Drug

plain ear drop formulation without moringa

Primary outcomes

  1. Number of participants recovered with clear endoscopic examination

    Time frame: one week

    Number of participants recovered with clear endoscopic examination

  2. Identification of different microorganisms infected ear

    Time frame: up to 1 month

    Patients swabs (microorganisms concentration)

Sponsors and collaborators

Lead sponsor

Deraya University

Other

Collaborators

  • Minia University

Registry information

Official study title

Antifungal Potential of Moringa Olifera-loaded Nanoparticles Against Otomycosis; Preparation, Characterization, and Clinical Evaluation

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Feb 24, 2021
Registry last updated
Mar 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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