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NCT Number: NCT07295210

Boric Acid Versus 10% Povidone Iodine Solution in Treatment of Otomycosis

This study compares two topical agents for the treatment of fungal infection of the external auditory canal: boric acid and a 10% povidone-iodine solution

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Key information

Conditions

Otomycosis Bacterial Infections and Mycoses Ear Diseases Infections Mycoses Otorhinolaryngologic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine, Mansoura University

Al Mansurah, Dakahlia Governorate, 35511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all consecutive patients with otomycosis, recruited from the outpatient clinic during the study duration

Exclusion criteria

  • tympanic membrane perforation
  • previous ear surgery
  • significant medical co-morbidities such as poorly controlled diabetes or immunocompromised patients
  • patient refusal to participate in the study

Treatment and study plan

Boric acid

Drug

Boric acid is topically applied to the external auditory canal for treatment of otomycosis

Povidone iodine 10%

Drug

10% povidone iodine solution is topically applied to the external auditory canal for the treatment of otomycosis

Primary outcomes

  1. objective clinical response

    Time frame: Days 7, 14, and 28 after treatment

    clinical response is assessed by ear examination by presence or absence of fungal hyphae inside the external auditory canal

  2. Microbiological response

    Time frame: day 28 after treatment

    Microbiological response is evaluated by obtaining cultures from the external auditory canal searching for fungal growth

Secondary outcomes

  1. subjective pain response

    Time frame: days 7, 14, and 28 after treatment

    pain is evaluated on a visual analogue scale from 0 to 10

  2. subjective itching response

    Time frame: days 7, 14, and 28 after treatment

    itching is evaluated on a visual analogue scale from 0 to 10

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Boric Acid Versus 10% Povidone Iodine Solution in Treatment of Otomycosis: a Randomized Clinical Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 19, 2025
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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