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OpenTrials
Completed

NCT Number: NCT02430272

Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.

The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

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Key information

Conditions

Fever Body Temperature Changes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

12 month–8 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ilsan Paik hospital

Goyang-si, Gyeonggi-do, 411-706, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists (ASA) Physical Status classification I
  • underwent surgery between 8 to 9 am
  • undergoing ambulatory anesthesia with ketamine

Exclusion criteria

  • who required endotracheal intubation
  • who were administered with medications other than ketamine

Treatment and study plan

Glycopyrrolate

Drug

Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group

Primary outcomes

  1. Body temperature

    Time frame: every 30 minutes from base line ( up to 90min )

    measured body temperature at three times in both ears and the highest value was selected.

Secondary outcomes

  1. Oral secretion (VAS)

    Time frame: up to operative end

    Oral secretion during the whole procedure was recorded by the researcher

Sponsors and collaborators

Lead sponsor

Inje University

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Apr 30, 2015
Registry last updated
May 1, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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