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OpenTrials
Completed

NCT Number: NCT00285688

Antibiotic Resistant Helicobacter Pylori in Rajavithi Hospital

Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin + Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%. This molecular genetic study will be performed in patients presenting with dyspepsia, who had an indication for gastroscopic examination, to explore the incidence of antibiotic resistant Helicobacter pylori in Rajavithi Hospital, Thailand.

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Key information

Conditions

Dyspepsia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rajavithi Hospital

Ratchathewi, Bangkok, 10400, Thailand

About this study

Genetic and Biomolecular factors determining clarithromycin resistance will be characterized.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male or female with dyspepsia
  • age > 15 years
  • fulfil indication for gastroscopic examination
  • able to give informed consent

Exclusion criteria

  • contraindication for gastroscopic examination and biopsy

Treatment and study plan

gastroscopic examination

Procedure

gastroscopic examination for tissue biopsy and real time PCR for gene study

Primary outcomes

  1. Incidence of H. pylori Clarithromycin resistance gene

    Time frame: one year

Secondary outcomes

  1. Characteristic of H. pylori clarithromycin resistant gene mutation

    Time frame: one year

Sponsors and collaborators

Lead sponsor

Department of Medical Services Ministry of Public Health of Thailand

Other Gov

Registry information

Official study title

Antibiotic Resistance Helicobacter Pylori and Clarithromycin Resistance Mutation in Helicobacter Pylori in Rajavithi Hospital

Important dates

Study start
2006
Primary completion
2007
Study completion
2007
First posted
Feb 2, 2006
Registry last updated
Oct 19, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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