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Completed

NCT Number: NCT06625736

Anti-obesity Effects of Dandelion (Taraxacum Officinale L.)

The study investigates the effectiveness of the natural product Dandelion in treating obesity in premenopausal women through a randomized interventional trial, measuring various parameters and biomarkers.

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Key information

Conditions

Obese Women Perimenopause

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

October 6 University Hospital

Giza, 12566, Egypt

About this study

The study aims to explore the anti-obesity effects of dandelion supplementation in premenopausal obese women. The research will measure changes in appetite, energy intake, body weight, composition, lipid profile, and inflammatory markers, providing evidence of dandelion's efficacy as an anti-obesity phototherapy. The randomized interventional trial will measure multiple parameters and biomarkers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Premenopausal women with obesity. Age between 18-45 years Stable body weight in the past 3 months

Exclusion criteria

Pregnancy Breastfeeding Diabetes Cardiovascular diseases kidney or liver diseases use of medications that affect body weight Smoking Allergy to dandelion or related plants

Treatment and study plan

Xenical

Drug

The Xenical group will receive identical capsules 120mg (one capsule) to be taken three times daily with meals, equaling 360mg total daily dose, which aligns with the usage in adult female patients

The dandelion extract

Dietary Supplement

The dandelion extract group will receive 500 mg capsules of dandelion leaf extract, given 3 times per day before meals.

Primary outcomes

  1. Changes in body weight

    Time frame: monthly change, assessed up to 3 months

  2. Change in fat mass

    Time frame: Monthly change, assessed up to 3 months

Secondary outcomes

  1. Appetite Ratings

    Time frame: monthly change, assessed up to 3 months

  2. Dietary intake via 24-hour recalls

    Time frame: Recorded for patients daily, assessed up to 3 months

  3. Lipid profile

    Time frame: Monthly change, assessed up to 3 months

  4. CRP

    Time frame: Monthly change, assessed up to 3 months

    C-reactive protein

  5. TNF-α

    Time frame: Monthly change, assessed up to 3 months

  6. IL-6

    Time frame: Monthly change, assessed up to 3 months

    Interelukine 6

  7. IL-16

    Time frame: Monthly change, assessed up to 3 months

  8. Glycemic indices

    Time frame: Monthly change, assessed up to 3 months

Sponsors and collaborators

Lead sponsor

October 6 University

Other

Collaborators

  • Pharos University in Alexandria

Registry information

Official study title

Anti-obesity Effects of Dandelion (Taraxacum Officinale L.) in Premenopausal Obese Women: Impacts on Appetite, Energy Intake and Lipid Metabolism

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 3, 2024
Registry last updated
Oct 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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