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NCT Number: NCT07522177

Animated Storytelling to Promote Colorectal Cancer Screening

This online randomized controlled trial will evaluate whether a short animated storytelling video increases behavioral expectation to obtain colorectal cancer screening among screening-eligible U.S. adults who report not yet having completed screening. Participants will be recruited via Prolific and randomized in Stanford Qualtrics to view either a brief animated video or a time-neutral informational text. Outcomes will be assessed immediately after exposure.

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Key information

Conditions

Colorectal Cancer Screening

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Stanford University

Stanford, California, 94305, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Resides in the United States
  • Able to read and understand English
  • Self-reports not having completed colorectal cancer screening
  • Provides electronic informed consent

Exclusion criteria

  • Prior diagnosis of colorectal cancer
  • Self-reported completion of colorectal cancer screening

Treatment and study plan

Short animated storytelling video

Behavioral

A brief animated storytelling video about colorectal cancer screening and colonoscopy.

Informational Text

Behavioral

A brief time-neutral informational text about colorectal cancer screening.

Primary outcomes

  1. Change from baseline in behavioral expectation (simple and next-step) to obtain colorectal cancer screening, as measured by a 7-item visual analogue scale.

    Time frame: Baseline, immediately post-intervention exposure (up to 24 hours)

    Participant self-reports their likelihood of discussing, scheduling, or obtaining colorectal cancer screening after exposure to assigned study material. Total scores range from 0-70 with higher scores indicating greater behavioral expectation (Item 7 is reverse scored).

Secondary outcomes

  1. Change from baseline in knowledge about colorectal cancer screening and colonoscopy, as measured by a 5-item knowledge questionnaire.

    Time frame: Baseline, immediately post-intervention exposure (up to 24 hours)

    Self-reported knowledge regarding colorectal cancer screening and the preventive role of colonoscopy, including detection and removal of pre-cancerous polyps. Response options are true/false/not sure, with 1 point per correct answer and 0 points for incorrect or "not sure". Total scores range from 0-5, with higher scores indicating higher knowledge.

  2. Change from baseline in perceptions and beliefs about colonoscopy, as measured by a 13-item scale.

    Time frame: Baseline, immediately post-intervention exposure (up to 24 hours)

    Self-reported perceptions an beliefs about colonoscopy include perceived susceptibility, perceived severity, perceived benefits and perceived barriers. Responses will be compared on a Likert scale that ranges from 1-5 (Strongly disagree / Disagree / Neither / Agree / Strongly agree), where higher scores indicate more positive perceptions and beliefs, with the perceived barriers section reverse scored.

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • Heidelberg University

Registry information

Official study title

Using Short Animated Storytelling to Increase Intent for Colorectal Cancer Screening: A U.S. Online Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 13, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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