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Active, Not Recruiting

NCT Number: NCT04259398

Anesthesia and Cancer Study: Colon Cancer

This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cancer of Colon Anesthesia Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site

Age range

19 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, South Korea

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About this study

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, total intravenous anesthesia (TIVA) is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, there is no randomized controlled study to determine this difference in colon cancer patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults undergoing surgery to remove colon cancer

Exclusion criteria

  • pregnancy
  • colon cancer with invasion to perineum
  • palliative surgery
  • history of diagnosis or surgery for other cancer
  • emergent surgery
  • ASA PS classification 4 and 5
  • refusion to participate in the study
  • allergy to anesthetics

Treatment and study plan

Propofol

Drug

propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

Sevoflurane

Drug

sevoflurane is administered for induction and maintenance of anesthesia

Primary outcomes

  1. five year survival

    Time frame: five years survival

    survival rate regardless of recurrence

Secondary outcomes

  1. five year recurrence free survival

    Time frame: five years after surgery

    survival rate without recurrence

  2. 1 year recurrence free survival

    Time frame: 1 year after surgery

    survival rate without recurrence

  3. 3 year recurrence free survival

    Time frame: 3 years after surgery

    survival rate without recurrence

  4. 1 year survival

    Time frame: 1 year after surgery

    survival regardless of recurrence

  5. 3 year survival

    Time frame: 3 years after surgery

    survival regardless of recurrence

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • Chung-Ang University Hospital
  • Korean Society of Anesthesiologists
  • Seoul National University Boramae Hospital
  • Seoul National University Bundang Hospital
  • Seoul St. Mary's Hospital

Registry information

Official study title

The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study

Important dates

Study start
2020
Primary completion
2028
Study completion
2028
First posted
Feb 6, 2020
Registry last updated
Nov 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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