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NCT Number: NCT06553313

Analysis of Protein Expression in Serum of KOA Subjects

In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults over 50 years old without knee pain

Exclusion criteria

  • Clinical diagnosis of knee osteoarthritis
  • Taking anti-inflammatory and analgesic drugs in the past month
  • Taking blood-lipid-lowering drugs or health foods in the past month
  • Received any acupuncture treatment in the past 3 weeks

Treatment and study plan

Micro-Western Array

Device

The subjects first took the energy measurement of the pulse sphygmograph and Ryodoraku, rested for 20 minutes, and then repeated the measurements again. In order to comply with the acupuncture treatment course was 5 weeks in the previous study, we have two blood draw point. Each subject's blood was drawn for the first time, and then for the second time in 5 weeks later. Each subject drew 10ml of blood each time. The blood samples are analyzed by Micro-Western Array (MWA) and Enzyme-linked immunosorbent assay (ELISA) to obtain the serum protein content value of healthy individuals.

Other names: Enzyme-linked immunosorbent assay, pulse sphygmograph, Ryodoraku

Primary outcomes

  1. Micro-Western Array and Enzyme-linked immunosorbent assay

    Time frame: the first and the fifth weeks

    Obtaining the serum protein content value

Secondary outcomes

  1. pulse sphygmograph and Ryodoraku

    Time frame: the first and the fifth weeks

    the energy measurement of pulse and meridians

Study contacts

Contact information is provided by the study sponsor or research team.

Wan-Zhen Yu

CONTACT

[email protected]

8864-22053366 ext. 3500

Yu-Chen Lee

CONTACT

[email protected]

8864-22053366 ext. 3500

Sponsors and collaborators

Lead sponsor

China Medical University Hospital

Other

Registry information

Official study title

Analysis of Protein Expression in Serum of Subjects With Knee Arthritis Control Group and Evaluation by Meridian and Pulse Wave Energy

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 14, 2024
Registry last updated
Aug 14, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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