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OpenTrials
Completed

NCT Number: NCT00957177

Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented.

Hyperalgesia is measured by von-Frey-Filaments.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Medical University of Graz

Graz, 8036, Austria

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients undergoing elective nephrectomy

Exclusion criteria

  • contraindication against pregabalin
  • creatinine > 2.0 mg/dl
  • GGT >165, AST >105, ALT >135
  • peptic Ulcus
  • haemorrhagic diathesis
  • angina pectoris, myocardial infarction
  • stroke
  • bronchial asthma
  • opioid abuse

Treatment and study plan

Pregabalin

Drug

300mg pregabalin orally 1 hour before operation

Other names: Lyrica

Placebo

Drug

Placebo

Other names: Control

Primary outcomes

  1. postoperative opioid consumption

    Time frame: 48 hours

Sponsors and collaborators

Lead sponsor

Medical University of Graz

Other

Registry information

Official study title

Effect of Preoperative Pregabalin Administration on the Postoperative Opioid Consumption in Patients Undergoing Nephrectomy

Acronym: PregabaNeph

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Aug 12, 2009
Registry last updated
May 27, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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