Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06707324

Analgesic Efficacy of Transversus Abdominis Plane Block Versus External Oblique Block in Patients Undergoing Elective Laparoscopic Cholecystectomy

Postoperative pain management is a critical aspect of recovery following laparoscopic cholecystectomy, a commonly performed procedure for symptomatic gallbladder disease. Effective analgesia not only enhances patient comfort but also facilitates early mobilization, reduces the incidence of complications, and improves overall outcomes.

Oblique subcostal transversus abdominis plane block (OSTAP), one of the regional anesthesia techniques, is used in middle and upper abdominal surgeries OSTAP blocks the T6-9 intercostal nerves between the rectus abdominis and transversus abdominis muscle. Many studies have shown that OSTAP block reduces the postoperative analgesic and opioid requirement and improves the quality of postoperative pain control.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Transversus Abdominis Plane Block External Oblique Block Laparoscopic Cholecystectomy

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of medicine, Assiut University, Assiut, Egypt,

Asyut, 71515, Egypt

Location contact

Ghada Abo Elfadl

CONTACT

[email protected]

01005802086

About this study

the potential mechanism of the external oblique intercostal fascial plane block (EOIB) in a cadaver study in which both lateral and anterior branches of the intercostal nerves T7-T10 were stained. Patients to whom this block was applied exhibited consistent dermatomal sensory blockade between T6-T10 in the anterior axillary line and T6-T9 in the midline. It has been shown that this block can be used in the clinical setting for upper abdominal wall analgesia.

Various adjuvants have been used to improve the quality and increase the duration of the local anesthetic action in different peripheral nerves and regional block techniques. dexamethasone microspheres have increased the block duration in both human and animal studies. Furthermore, dexamethasone has been shown to possess antiinflamatory action.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aged 18-60 years.
  • Gender: Both males and females.
  • BMI less than 35 kg/m2
  • Scheduled for laparoscopic cholecystectomy surgery
  • American Society of Anesthesiologists - ASA - I & II

Exclusion criteria

1-ASA physical status more than II. 2-History of allergic response to local anaesthetics or any of the medications used in the study

-

Treatment and study plan

drug injected between the rectus abdominis muscle and the transversus abdominis muscle

Procedure

20 ml of 0.25% bupivacaine + 8 mg dexamethasone between the rectus abdominis muscle and the transversus abdominis muscle on both sides

drug injected in the external oblique intercostal plane on both sides

Procedure

20 ml of 0.25% bupivacaine+ 8 mg dexamethasone into the external oblique intercostal plane on both sides

Primary outcomes

  1. the first analgesic request depending on Numeric Rating Scale

    Time frame: 24hours

    the first analgesic request depending on Numeric Rating Scale

Study contacts

Contact information is provided by the study sponsor or research team.

Ghada Ghada Abo Elfadl, Asossciated professor

CONTACT

[email protected]

[email protected]

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 27, 2024
Registry last updated
Dec 3, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.