Skip to main content
OpenTrials
Completed

NCT Number: NCT04650100

Analgesic Effectiveness of PENG Block in Programmed Hip Arthroplasty Surgery

The intra- and peri-articular infiltration of local anaesthetics realized at the end of total hip arthroplasty surgeries is an effective analgesic technique, but it can be insufficient to manage the possibly intense postoperative pain. Regional anaesthesia (RA) like the recently described pericapsular nerve group (PENG) block could provide additional analgesic benefit in this setting.

Investigators main objective is to demonstrate the analgesic benefits (postoperative pain score and morphine consumption) of the PENG block when added to intra- and peri-articular infiltration of local anaesthetic following total hip arthroplasty. Investigators make the assumption that i) the PENG bloc could reduce the postoperative 24 first hours morphine consumption by 30%, ii) the PENG block could spare the motor function of the quadriceps and adductor muscles, and iii) the PENG bloc could be well tolerated allowing a high level of patient satisfaction.

Completed

Looking for future studies?

Notify Me

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital of Toulouse

Toulouse, France

About this study

A recent study has revealed a region of pericapsular terminal branches of the femoral nerve and the obturator nerve accessible to ultrasound-guided regional anaesthesia. This technique, also called the PENG block, has recently been described with a substantial benefit on pain at rest and induced by mobilization in cases series of patients undergoing hip fracture surgery. To investigators knowledge, no randomized data concerning the analgesic efficacy of the PENG block has been published in the setting of elective total hip arthroplasty.

The PENG block would allow a significant analgesic contribution when added to intra- and peri-articular infiltration of local anaesthetics while being well tolerated with few undesirable effects. Moreover, the PENG block could spare the motor function of the quadriceps and adductor muscles allowing enhanced recovery after surgery

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Scheduled for total hip arthroplasty surgery under general anaesthesia
  • Affiliated of a social security scheme
  • Having signed the written informed consent

Exclusion criteria

  • Total hip arthroplasty revision surgery
  • Refusal of the patient to participate
  • Existence of major spontaneous or acquired haemostasis disorders
  • Infection at the puncture site
  • Allergy to local anaesthetics
  • Pregnancy or breast-feeding
  • Patients under the protection of adults (guardianship, curatorship or protection of justice)
  • Patients whose cognitive state does not allow assessment by the scales used.

Treatment and study plan

ultrasound-guided PENG bloc realized before surgery

Procedure

ultrasound-guided PENG block realized before surgery. The PENG block, described by Giron-Arebgi is made in the supine position. The ultrasound probe used is a 5 MHz high frequency linear probe placed parallel to the line delimited by the anterior-inferior iliac spine (lateral) and the pubis (medial). The needle used is an 80 mm, 22G, needle inserted in the ultrasound plane. The slow and fractioned injection of 20 ml of Ropivacaine 4.75 mg/ml is performed in the fascia between the psoas tendon and the iliopubic eminence under ultrasound guidance.

Primary outcomes

  1. Cumulated postoperative morphine consumption 24 hours after surgery

    Time frame: 24 hours

    calcul of Cumulated postoperative morphine consumption 24 hours after surgery

Secondary outcomes

  1. Cumulated postoperative morphine consumption in the post anaesthesia care unit (PACU)

    Time frame: Hour 1

    Cumulated postoperative morphine consumption in the post anaesthesia care unit (PACU)

  2. Cumulated postoperative morphine consumption 48 hours after surgery

    Time frame: Hour 48

    Cumulated postoperative morphine consumption 48 hours after surgery

  3. Evaluation of pain in the PACU

    Time frame: Hour 1

    Evaluation of pain using a simple numeric rating scale (NRS from 0 to 10) in the PACU

  4. Evaluation of pain 24 hours after surgery

    Time frame: Hour 24

    Evaluation of pain using a simple numeric rating scale (NRS from 0 to 10) 24 hours after surgery

  5. Evaluation of pain 48 hours after surgery

    Time frame: Hour 48

    Evaluation of pain using a simple numeric rating scale (NRS from 0 to 10) 48 hours after surgery

  6. Evaluation of the pain potentially induced by the realization of the PENG block

    Time frame: Hour 0

    Evaluation of the pain potentially induced by the realization of the PENG block with Likert scale from 1 to 5, 1 is for no pain, 5 is for the worse pain

  7. Evaluation of adverse effects associated with the PENG block

    Time frame: Hour 0

    Evaluation of adverse effects associated with the PENG block

  8. Evaluation of adverse effects associated with the PENG block

    Time frame: Hour 1

    Evaluation of adverse effects associated with the PENG block

  9. Evaluation of adverse effects associated with the PENG block

    Time frame: Hour 24

    Evaluation of adverse effects associated with the PENG block

  10. Evaluation of adverse effects associated with the PENG block

    Time frame: Hour 48

    Evaluation of adverse effects associated with the PENG block

  11. Evaluation of adverse effects associated with the use of morphine

    Time frame: Hour 0

    Evaluation of adverse effects associated with the use of morphine

  12. Evaluation of adverse effects associated with the use of morphine

    Time frame: Hour 1

    Evaluation of adverse effects associated with the use of morphine

  13. Evaluation of adverse effects associated with the use of morphine

    Time frame: Hour 24

    Evaluation of adverse effects associated with the use of morphine

  14. Evaluation of adverse effects associated with the use of morphine

    Time frame: Hour 48

    Evaluation of adverse effects associated with the use of morphine

  15. Evaluation of the patients' satisfaction

    Time frame: Hour 24

    Evaluation of the patients' satisfaction by the EVAN-LR score realized 24 hours after surgery. EVAN-LR is a scale assessing perioperative patient's satisfaction with Loco Regional anaesthesia

  16. Evaluation of the adductor muscles weakness

    Time frame: Hour 24

    Evaluation of the adductor muscles weakness by a thigh adduction test performed 24 hours after surgery

  17. Evaluation of the quadricipital muscles weakness

    Time frame: Hour 24

    Evaluation of the quadricipital muscles weakness by a Timed to Up and Go Test performed 24 hours after surgery

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Acronym: THAPeng

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Dec 2, 2020
Registry last updated
Nov 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.