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Completed

NCT Number: NCT06129123

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

The goal of this intervention development and pilot clinical trial is to determine whether receiving the brief online intervention results in greater reductions in past 7-day e-cigarette use frequency and smoking susceptibility over an 8-week period compared to receiving the control condition in young adults who currently use e-cigarettes. Participants in the experimental condition will be asked to complete the 30-minute mobile-based program. Participants in the assessment-only control will be given the option to access the intervention after they complete their final survey at 8 weeks. All participants will complete our online surveys at baseline as well as 2-weeks, 4-weeks, and 8-weeks post-randomization. Researchers will compare outcomes among the intervention and control groups to determine the efficacy of the intervention.

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Key information

Conditions

E-cigarette Use Behavior Smoking Vaping

Age range

18 year–24 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Southern California

Los Angeles, California, 90089, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • be between the ages of 18 to 24
  • be able to read English
  • report vaping at least one day per week in the past month
  • report no history of cigarette use at screening and baseline.

Exclusion criteria

  • reporting severe mental health, illicit drug use, or alcohol use disorder
  • currently receiving nicotine cessation services

Treatment and study plan

Live Free From E-cigarettes

Behavioral

This is a 30-minute online educational program that focuses on providing information about e-cigarette and smoking social norms, harms of e-cigarettes and cigarettes, and ways to quit or reduce using e-cigarettes.

Primary outcomes

  1. E-cigarette Use

    Time frame: 8 weeks

    Participants will report the number of (1) days they vaped, (2) times they picked up their device to vape per day, and (3) puffs they took before putting their vaping device away per day in the past 7 days and 30 days

  2. Smoking Susceptibility

    Time frame: 8 weeks

    4-item Expanded Susceptibility to Smoking Index (ESSI)

Secondary outcomes

  1. Perceived harms and benefits of vaping

    Time frame: 8 weeks

    Using the 21-item Short Form Vaping Consequences Questionnaire (S-VSQ), participants will rate the likelihood that each consequence will occur when they vape.

  2. Perceived harms and benefits of smoking

    Time frame: 8 weeks

    Using the 21-item Short Form Smoking Consequences Questionnaire (S-SCQ), participants will rate the likelihood that each consequence will occur when they smoke.

  3. Motivation to vape

    Time frame: 8 weeks

    Participants will select which option best describes their interest in e-cigarette use: plan to stop (coded as 1), decrease (2), continue (3) or increase (4) vaping.

  4. Motivation to smoke

    Time frame: 8 weeks

    Participants will report if they plan to start smoking (yes/no).

  5. Quitting vaping self-efficacy

    Time frame: 8 weeks

    Participants rate their confidence about quitting vaping "someday" and "in the next 6 months" on a 5-point scale.

  6. Vaping quit attempts

    Time frame: 8 weeks

    During follow-up assessments, participants will report on the number of times they have stopped vaping for one day or longer because they were trying to quit vaping.

Sponsors and collaborators

Lead sponsor

University of Southern California

Other

Registry information

Official study title

Development of An Online, Theory-Based Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults: A Pilot Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 13, 2023
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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