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Completed

NCT Number: NCT02298049

An fMRI Study of Satiation in Healthy Volunteers.

To our knowledge no study has assessed the effects of a meal on neural responses to food cues and compared this with a condition simulating natural inter-meal hunger levels. This is important, as the existing literature often compares the effect of fasting to satiation, which may not reflect typical appetite processes. Thus, the purpose of this research was to examine the effect of a satiating lunch compared to a normal pre-meal state on blood oxygen level dependent (BOLD) activity in the human brain, as measured using functional magnetic resonance imaging (fMRI).

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Key information

Conditions

Appetite

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Birmingham

Birmingham, West Midlands, B15 2TT, United Kingdom

About this study

We hypothesized that satiation would be associated with decreased brain activity across brain regions involved in both appetite and reward such as ventromedial prefrontal cortex, orbitofrontal cortex, ventral striatum, hypothalamus, insula, amygdala and hippocampus. 16 healthy participants (8 males) were scanned on two separate test days, before and after eating a meal to satiation, or after not eating for 4 hours (satiated vs. pre-meal). fMRI BOLD signals to the sight and/or taste of the stimuli were recorded. Participants were given questionnaires to complete about their mood state and appetite before and after all scans.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers
  • Sufficiently fluent in English to understand the task and the instructions

Exclusion criteria

  • Currently taking medication
  • Past or current depression/dieting,
  • Smokers
  • Food allergies
  • Diabetes
  • Pregnancy
  • BMI score outside the normal range
  • Any contraindications to fMRI scanning (e.g. pacemakers, mechanical heart valve, hip replacement, metal implants)

Treatment and study plan

Satiated / Pre-meal

Other

All participants were scanned before and after not being fed (pre-meal), and before and after being given a satiating lunch (satiated).

MRI

Device

Primary outcomes

  1. Activation differences between satiated and pre-meal scan fMRI BOLD signal

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Birmingham

Other

Collaborators

  • University of Oxford

Registry information

Official study title

Satiation Attenuates BOLD Activity in Brain Regions Involved in Reward and Increases Activity in an Inhibitory Control Area: an fMRI Study in Healthy Volunteers.

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Nov 21, 2014
Registry last updated
Nov 21, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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