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NCT Number: NCT07086859

Alveolar Ridge Preservation Using Autogenous Whole Tooth Graft With 1 %Metformin :A Randomized Controlled Clinical Trial

This study describes a technique used to preserve the bone dimensions after the tooth extraction inorder to facilitate later on the dental implant placement

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Key information

Conditions

Dimensional Changes After Tooth Extraction Socket Preservation Tooth Extraaction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo Univeristy

Giza, Egypt

Location contact

Nada Gadallah, Masters Degree Candidate

PRINCIPAL_INVESTIGATOR

About this study

Socket preservation by type of graft used from the tooth combined with Metformin to enhace the results of the bone formation

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 years or older
  • patients requiring single extraction of non-molar tooth
  • extraction sockets having more than 50% buccal alveolar bone loss

Exclusion criteria

  • Pregnancy
  • smokers
  • patients not maintaing good oral hygiene
  • presernce of acute endodontic infection in the tooth to be ectracted
  • medical conditions hindering implant placement
  • uncontrolled diabetes
  • Immune suppression
  • bisphosphanates

Treatment and study plan

TEST 1

Procedure

Autogenous whole tooth graft with metformin

Control

Procedure

Autogenous whole tooth graft

Primary outcomes

  1. Radiographic buccolingual width ridge loss

    Time frame: 6 months

    Measuring the CBCT these dimensions pre operative and after 6 months

Secondary outcomes

  1. Alveolar buccal ridge height, lingual ridge height

    Time frame: 6 months

    Measuring them on CBCT pre operative and after 6 months

  2. the area percentage of newly formed bone, soft tissue and residual graft

    Time frame: 6 months

    By Histology after taking a biopsy after 6 months

  3. Patient satisfaction evaluation

    Time frame: 2 weeks

    by visual analog scale (0-10)

  4. Total number of analgesics taken in the first week

    Time frame: 1 week

    by asking the patient

  5. Socket wound healing score

    Time frame: 2 weeks

    by taking occlusal clinical pictures of socket

Study contacts

Contact information is provided by the study sponsor or research team.

Nada Gadallah, Masters Degree Candidate

CONTACT

[email protected]

+201000130279

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jul 25, 2025
Registry last updated
Jul 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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