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NCT Number: NCT07595445

Injectable Alloplastic Bone Graft for Socket Preservation: Clinical, Radiographic, and Histological Evaluation

This study will evaluate the clinical efficacy of injectable alloplastic bone grafts in terms of radiography and histology in order to preserve tooth sockets following extraction. Methodology: Twenty new extraction sockets from twenty surgically extracted non-restorable mandibular molar teeth will be used in this clinical investigation.

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Key information

Conditions

Tooth Extraction Socket Preservation

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Using computer randomization (http://www.randomlists.com), the 20 extraction sockets will be split into two equal groups (n=10) at random. Ten sockets (the experimental group) will undergo socket preservation using injectable bone substitute biomaterial. To permit normal physiological healing, the remaining 10 sockets (control group) will left unfilled. Clinical examination will be carried out after 2 days, 1 week, 2 weeks, 1 month, and 4 months, while after 4 months, radiographic measurements of bone dimension changes were carried out, and the histological inspection will be carried out three months after the removal of the tooth.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient aged between 40 and 60 years.
  • General good health.
  • Presence of a hopeless mandibular posterior tooth that requires extraction.
  • Volunteer subjects have to voluntarily sign an informed consent.
  • Patient Indicated for implant.

Exclusion criteria

  • Patient with systemic disease affection bone metabolism.
  • Large periapical radiographic changes related to the tooth to be Extracted, in the form of abscess, granuloma, or cyst.
  • Teeth need trans-alveolar extraction.
  • Patients with contraindication to surgical treatment.
  • Patients suffering from a psychological disorder.
  • Patients with uncontrolled medical conditions.

Treatment and study plan

Injectable Alloplastic Bone

Procedure

Ten extraction sockets will undergo socket preservation using injectable bone substitute biomaterial following atraumatic tooth extraction and socket curettage.

natural healing (no graft)

Procedure

Ten extraction sockets will be left unfilled after atraumatic extraction to allow normal physiological healing.

Primary outcomes

  1. Change in buccolingual ridge width assessed by CBCT

    Time frame: Baseline and 4 months

    Buccolingual ridge width will be measured radiographically using CBCT immediately post-extraction (baseline) and after 4 months

  2. Bone density assessed by CBCT

    Time frame: Baseline and 4 months

    Bone density of the extraction socket will be evaluated radiographically using CBCT gray values immediately post-extraction (baseline) and after 4 months.

  3. Percentage of newly formed bone assessed histomorphometrically

    Time frame: 3 months

    The percentage of newly formed bone will be evaluated histomorphometrically using hematoxylin and eosin staining during implant placement.

  4. Percentage of residual graft material

    Time frame: 3 months

    Residual graft material percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement.

  5. Percentage of connective tissue

    Time frame: 3 months

    Connective tissue percentage will be assessed histomorphometrically using hematoxylin and eosin staining during implant placement.

Secondary outcomes

  1. Mucosal healing

    Time frame: Up to 4 months

    Clinical mucosal healing will be assessed by the presence or absence of infection, swelling, and adverse tissue reaction during follow-up visits.

Study contacts

Contact information is provided by the study sponsor or research team.

Moataz Selmi

CONTACT

[email protected]

01006848382

Sponsors and collaborators

Lead sponsor

Suez Canal University

Other

Registry information

Official study title

Clinical, Radiographic, and Histological Evaluation of Injectable Alloplastic Bone Graft in Extraction Socket Preservation

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 19, 2026
Registry last updated
May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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