Università degli Studi di Cagliari
Cagliari, California, 09042, Italy
NCT Number: NCT07086625
The primary objective of the study is to develop and validate a machine learning model for the automatic identification of periodontal vertical bone defects, improving diagnostic accuracy and efficiency.
The study comprises three phases:
1. Public dataset annotation: Approximately 7,000 intraoral radiographs will be manually annotated by experts to classify periodontal bone defects (1-wall, 2+ walls, craters, furcation involvement). 2. Model training: A deep learning algorithm will be trained on the annotated images to learn automatic recognition of the defects. 3. Clinical validation: The model will be tested on a dataset of 150 anonymized radiographs from 20-30 patients treated at AOU (Azienda Ospedaliero Universitaria) Cagliari, comparing its performance to expert dental evaluations.
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Observational
Cagliari, California, 09042, Italy
To address the challenge of detecting periodontal osseous defects, the study will employ the YOLOv8 (You Only Look Once versione 8) framework, a state-of-the-art deep learning model optimized for object detection tasks. This architecture is known for its balance between accuracy and inference speed, making it suitable for clinical applications that require efficient processing.
The YOLOv8l (large) variant will be selected to maximize detection accuracy, given the complexity of the task. The architecture will include:
Model Training
The training will be performed on a dataset consisting of approximately 406 images for training, 58 for validation, and 117 for testing. Annotations will include bounding boxes for four types of defects: 1-wall, 2+ walls, craters, and furcation involvement. The dataset will be formatted according to YOLO standards.
Key training parameters will include:
Inference and Evaluation
Inference will be conducted on the test set, and model performance will be evaluated using standard object detection metrics. These will include:
Performance will be summarized using mean Average Precision (mAP):
The model's detection capabilities will be assessed across all four classes of periodontal bone defects, providing a comprehensive evaluation of its diagnostic potential.
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time frame: Baseline
The IoU measures the overlap between a predicted bounding box and a ground truth bounding box. It is defined as: Area of Overlap/Area of Union; where the area of overlap is the intersection of the predicted and ground truth boxes, and the area of union is the total area covered by both boxes.
Time frame: Baseline
The fraction of true positives (TP) among all predictions:
T P/T P + F P High precision indicates that the model makes few false positive (FP) predictions.
Time frame: Baseline
The fraction of true positives among all ground truth objects:
T P/T P + F N (false negatives) High recall indicates that the model detects most ground truth objects.
University of Cagliari
Other
AI-Based Radiographic Detection of Periodontal Infrabony and Furcation Defects: A Diagnostic Model Study
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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