African Studies on Aging and Noncommunicable Diseases Epidemiology

Despite the rising burden of noncommunicable diseases (NCDs), including cardiovascular diseases (CVDs), across Africa, high-quality evidence on the distribution of NCDs and their risk factors remains strikingly scarce. Many global estimates continue to rely on limited empirical data from African countries, and this persistent data gap has led major international research collaborations to underrepresent the continent. This reality highlights an urgent need for granular, context-specific, and methodologically robust data on NCDs and their determinants across Africa.

The African Studies on Ageing and Noncommunicable Disease Epidemiology (ASANDE) initiative responds directly to this need by assembling harmonized, individual-level datasets from African populations, complemented by comparable data from other global regions. With recruitment underway, ASANDE seeks to quantify and compare the associations between major NCD risk factors, including cardiometabolic, behavioral, and environmental determinants, and the incidence and mortality of major NCD outcomes (cardiovascular diseases, cancer, chronic respiratory diseases, diabetes, and other NCDs) across world regions, with a particular emphasis on disparities between African populations and the rest of the global population.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Cardio Vascular Disease Cancer Cardiovascular Mortality Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institut Pasteur de Dakar; Address: 36, Avenue Pasteur, B.P. 220 - Dakar, Senegal

Dakar, Senegal

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

We included cross-sectional surveys and longitudinal population-based studies providing individual-level data on established noncommunicable disease (NCD) risk factors, including body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking status, and diabetes mellitus, together with information on predefined NCD outcomes of interest (including cardiovascular diseases, cancer, chronic respiratory diseases, and other major NCDs). For longitudinal studies, prospective ascertainment of incident events and mortality was required.

Exclusion criteria

Participants were excluded if they were younger than 18 years at the time of assessment, had missing data on the outcome of interest, had no available information on the exposure variables (NCD risk factors), or, for longitudinal analyses, had a documented history of the respective NCD outcome at baseline.

Treatment and study plan

Primary outcomes

non communicable diseases

Time frame: Median follow-up of approximately 10 years across cohorts.

Event rates of noncommunicable diseases (NCDs) and NCD subtypes: First fatal or non-fatal diagnosis of cardiovascular diseases (including myocardial infarction, unstable angina, coronary revascularization, ischemic or hemorrhagic stroke), cancer, chronic respiratory diseases (including chronic obstructive pulmonary disease and asthma), type 2 diabetes mellitus, chronic kidney disease, or other major NCD-related outcomes, as well as NCD-related or unclassifiable death. The type of outcome measurement varies across cohorts. NCD cases and subtypes are assessed through self-reported questionnaire information, clinical examinations, medical record validation, national hospital discharge registry data, disease-specific registries (e.g., cancer registries), causes of death registry data, or central death registries, depending on the study protocol of the respective cohort studies.

Sponsors and collaborators

Lead sponsor

Alliance For Medical Research in Africa

Network

Collaborators

Institut Pasteur de Dakar

Registry information

Acronym: ASANDE

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2030
First posted: Feb 23, 2026
Registry last updated: Feb 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Active, Not Recruiting