Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease

This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.

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Key information

Conditions

Inflammation Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Disease Periodontal Diseases Stomatognathic Diseases

Age range

18 year–66 year

Sex eligibility

All sexes

Study type

Observational

About this study

Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.

Advanced oxidation protein product is identified as a new marker of protein oxidation.

Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of chronic periodontitis and gingivitis

Exclusion criteria

Systemic illnesses
Any medications known to affect the periodontium
Pregnancy and lactation

Treatment and study plan

Primary outcomes

Advanced oxidation protein product (nmol)

Time frame: Before periodontal treatment

Secondary outcomes

Monocyte chemoattractant protein-1(pg)

Time frame: Before periodontal treatment
The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3)

Time frame: Before periodontal treatment

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Official study title

The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Jul 28, 2016
Registry last updated: Jul 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed