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Completed

NCT Number: NCT07695857

Adropin Levels in Periodontal Disease

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

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Key information

Conditions

Periodontitis Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

27 year–49 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Giresun University

Giresun, Turkey (Türkiye)

About this study

Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • having at least 20 natural teeth, excluding third molars
  • having no systemic disease
  • non-smokers
  • Diagnosed with periodontally health and periodontitis patients

Exclusion criteria

  • having any systemic diseases
  • smoking
  • current pregnancy or lactation
  • a history of periodontal treatment in the past 6 months
  • using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Treatment and study plan

Nonsurgical periodontal therapy

Procedure

Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.

Primary outcomes

  1. 1. Adropin levels

    Time frame: Baseline and at 6 weeks after therapy

    Changes in Adropin levels before and after periodontal therapy

Secondary outcomes

  1. TNF-alfa levels

    Time frame: baseline and at 6 weeks after therapy

    Changes in TNF-alfa levels before and after periodontal therapy

Sponsors and collaborators

Lead sponsor

Giresun University

Other

Collaborators

  • Aydin Adnan Menderes University

Registry information

Official study title

Adropin Levels in GCF and Serum of Periodontitis Patients

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Jul 10, 2026
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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