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Completed

NCT Number: NCT05227586

Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation With Right Atrial Enlargement

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive right atrial ablation.

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Key information

Conditions

Persistent Atrial Fibrillation Arrhythmias, Cardiac Atrial Fibrillation Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Right Atrial Enlargement

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mu Qin

Shanghai, 200030, China

About this study

This is retrospective cohort study testing whether patients with persistent atrial fibrillation and right atrial enlargement may benefit from adjunctive RA ablation.

We enrolled 65 patients with persistent atrial fibrillation and right atrial enlargement received adjunctive right atrial ablation. These patients were 1:2 match with 130 patients received left atrial ablation only. Atrial fibrillation recurrence rate and other paremeters were analyzed to evaluate the efficacy of adjunctive right atrial ablation in this subset of patients.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 to 80 years old;
  • Persistent AF with right atrial enlargement;
  • Nonresponse or intolerance to ≥1 antiarrhythmic drug.

Exclusion criteria

  • History of catheter ablation;
  • valvular heart disease;
  • hypertrophic cardiomyopathy or dilated cardiomyopathy;
  • Without follow-up data

Treatment and study plan

Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation

Procedure

Patients receive circumferential pulmonary vein isolation and linear ablation (ablation of a roof line and a mitral isthmus line) combined with bi-atrial mapping and left atrial driver ablation.

Circumferential pulmonary vein isolation + linear ablation + bi-atrial mapping + left atrial driver ablation + right atrial driver ablation

Procedure

Patients receive circumferential pulmonary vein isolation and linear ablation (ablation of a roof line and a mitral isthmus line) combined with bi-atrial mapping , left atrial driver ablation and right atrial driver ablation.

Primary outcomes

  1. atrial fibrillation (AF) recurrence rate

    Time frame: at 12 months post procedure

    AF recurrence is defined as presence of documented AF episodes of 30 seconds or longer duration

Secondary outcomes

  1. atrial fibrillation (AF)/atrial flutter (AFL)/atrial tachycardia (AT) recurrence rate

    Time frame: at 12 months post procedure

    AF/AFL/AT recurrence is defined as presence of documented AF/AFL/AT episodes of 30 seconds or longer duration

Sponsors and collaborators

Lead sponsor

Shanghai Chest Hospital

Other

Registry information

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 7, 2022
Registry last updated
Feb 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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