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NCT Number: NCT07446127

Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy

The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:

To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.

This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:

Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups

Recruiting

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Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Atrophy Periodontal Attachment Loss Periodontal Diseases Periodontal Pocket Periodontal Pockets Periodontitis Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dr Younis Mahmoud

Afula, North, 1839203, Israel

Location status: Recruiting

Location contact

Mahmoud Dt Younis, DMD

CONTACT

[email protected]

+972544934823

Mahmoud Younis, DMD

PRINCIPAL_INVESTIGATOR

Michael Dr Saminsky, DMD

CONTACT

[email protected]

+972545508436

Michael Saminsky, DMD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy patients
  • Each patient should have more than 20 teeth remaining, and at least 5 teeth per quadrant
  • Each patient presented ≥ 30% of sites involved
  • At least 2 teeth with a probing depth of ≥ 5 mm in each quadrant, with evident radiographic bone loss.

Exclusion criteria

  • History of systemic diseases affecting the periodontium
  • Smokers and alcoholic patients
  • Use of medication within the last 6 months, which might affect the periodontal status
  • Pregnant and lactating women
  • Patients who had any periodontal treatment ≤ 12 months before the examination.

Treatment and study plan

LASER assisted SRP

Device

Two quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only

RsD

Device

mechanical root surface debridement with periodontal curettes

Primary outcomes

  1. PPD

    Time frame: prior to treatment and 12 weeks and 6 months after treatment

    periodontal pocket depth

Secondary outcomes

  1. CAL

    Time frame: prior to treatment and 12 weeks and 6 months after the treatment

    clinical attachment level

  2. BOP

    Time frame: prior to treatment and 12 weeks and 6 months after the treatment

    bleeding on probing

Study contacts

Contact information is provided by the study sponsor or research team.

Mahmoud Dr Younis, DMD

CONTACT

[email protected]

+972544934823

Sponsors and collaborators

Lead sponsor

Tel Aviv University

Other

Registry information

Official study title

Evaluation of the Effect of Adjunctive Diode Laser Therapy in Mechanical Scaling and Root Surface Debridement in Non-Surgical Periodontal Therapy

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 3, 2026
Registry last updated
Mar 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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