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Completed

NCT Number: NCT03856801

Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

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Key information

About this study

  • Crossover.
  • 13 patients with multiple sclerosis were recruited.
  • Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • mild or moderate disability with clinical mild spastic-ataxic gait disorder.
  • stable phase of the disease.

Exclusion criteria

  • Expanded Disability Status Scale (EDSS) < 6.
  • relapsing disease within the preceding 12 months.
  • corticosteroid treatment within the last months before study inclusion.

Treatment and study plan

Exercise

Other

Whole-body vibration training in hypoxia and normoxia condition

Primary outcomes

  1. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: Immediately before the training sessions

  2. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: Immediately after the training sessions

  3. Rate of Force Development

    Time frame: Immediately before the training sessions

  4. Rate of Force Development

    Time frame: Immediately after the training sessions

  5. Central Activation Ratio

    Time frame: Immediately before the training sessions

  6. Central Activation Ratio

    Time frame: Immediately after the training sessions

  7. Biomechanical study of the walk by video recording

    Time frame: Immediately before the training sessions

    Kinematic analysis of knee and ankle angles during walking

  8. Biomechanical study of the walk by video recording

    Time frame: Immediately after the training sessions

    Kinematic analysis of knee and ankle angles during walking

  9. Biomechanical study of the walk by video recording

    Time frame: Immediately before the training sessions

    Stride amplitude during walking

  10. Biomechanical study of the walk by video recording

    Time frame: Immediately after the training sessions

    Stride amplitude during walking

  11. Spasticity

    Time frame: Immediately before the training sessions

    Pendulum test

  12. Spasticity

    Time frame: Immediately after the training sessions

    Pendulum test

Secondary outcomes

  1. Rate of Perceived Exertion

    Time frame: Immediately before the training sessions

    RPE Scale 6-20

  2. Rate of Perceived Exertion

    Time frame: Immediately after the training sessions

    RPE Scale 6-20

  3. Walking speed

    Time frame: Immediately before the training sessions

    Test 10 m-walks

  4. Walking speed

    Time frame: Immediately after the training sessions

    Test 10 m-walks

  5. Static balance

    Time frame: Immediately before the training sessions

    Romberg Test with eyes open and closed. Analysis with force plates

  6. Static balance

    Time frame: Immediately after the training sessions

    Romberg Test with eyes open and closed. Analysis with force plates

  7. Muscle oxygenation in soleus

    Time frame: Immediately before the training sessions

    MOXY's

  8. Muscle oxygenation in soleus

    Time frame: Immediately after the training sessions

    MOXY's

Sponsors and collaborators

Lead sponsor

Universidad Católica San Antonio de Murcia

Other

Registry information

Official study title

Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Feb 27, 2019
Registry last updated
Feb 27, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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