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Completed

NCT Number: NCT00740896

Acute Effects of Smoking on Airway Dendritic Cells

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Completed

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Key information

Conditions

Tobacco Use Disorder Behavior Chemically-Induced Disorders Cigarette Smoking Mental Disorders Smoking Substance-Related Disorders Tobacco Smoking Tobacco Use

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Rostock

Rostock, 18057, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Active smoking (at least 10 cigarettes per day)
  • Age > 18 years

Exclusion criteria

  • Any chronic diseases
  • Any regular medication
  • Any signs or symptoms of an acute infection

Treatment and study plan

smoking

Behavioral

Active Comparator: Participants smoke 8 cigarettes in 4 hours.

Primary outcomes

  1. Total number of dendritic cells in bronchoalveolar lavage fluid

    Time frame: June - September 2008

Secondary outcomes

  1. Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid

    Time frame: June - September 2008

Sponsors and collaborators

Lead sponsor

University of Rostock

Other

Collaborators

  • German Research Foundation

Registry information

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Aug 25, 2008
Registry last updated
Apr 8, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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